Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong, China.
Aust Dent J. 2012 Mar;57(1):65-70. doi: 10.1111/j.1834-7819.2011.01641.x.
This study aimed to investigate the effect of silver and fluoride ions on demineralization of enamel.
The coronal parts of 40 extracted sound premolars were prepared into tooth blocks. An unvarnished occlusal surface window (OW) and a flat buccal/lingual surface window (FW) were created for each tooth by covering all other surfaces with an acid-resistant varnish. These blocks were randomly allocated into four groups of 10 blocks each and immersed in respective solutions for 5 minutes: Group 1--2.36 M silver fluoride; Group 2--2.36 M potassium fluoride; Group 3--2.36 M silver nitrate; and Group 4--deionized water. After 7-day immersion in a buffered demineralization solution at pH 4.4, micro-CT scans were taken.
Mean lesion depth in the FW area for tooth blocks in AgF, KF, AgNO(3) and control groups were 0 μm, 3.3 ± 10.3 μm, 156.3 ± 30.8 μm, and 173.6 ± 48.6 μm, respectively (p < 0.001). The difference in mean lesion depth between the AgNO(3) and control groups was not statistically significant (p > 0.05). Similar OW and FW lesions were observed in tooth blocks in the AgNO(3) and control groups.
Topical application of a 2.36 M fluoride solution can inhibit demineralization of enamel while topical application of silver ions has little effect.
本研究旨在探讨银离子和氟离子对牙釉质脱矿的影响。
将 40 颗离体健康前磨牙的牙冠部分制备成牙块。用耐酸漆覆盖所有其他表面，在每个牙上制备未上釉的咬合面窗口（OW）和颊/舌面平面窗口（FW）。将这些牙块随机分为 4 组，每组 10 个牙块，分别浸泡在以下溶液中 5 分钟：组 1——2.36M 氟化银；组 2——2.36M 氟化钾；组 3——2.36M 硝酸银；组 4——去离子水。7 天后，将牙块在 pH4.4 的缓冲脱矿溶液中浸泡，进行微 CT 扫描。
FW 区域牙块的平均病变深度在 AgF、KF、AgNO3 和对照组分别为 0μm、3.3±10.3μm、156.3±30.8μm 和 173.6±48.6μm（p<0.001）。AgNO3 组和对照组之间平均病变深度的差异无统计学意义（p>0.05）。AgNO3 组和对照组的牙块观察到类似的 OW 和 FW 病变。
局部应用 2.36M 氟化物溶液可抑制牙釉质脱矿，而局部应用银离子对脱矿影响较小。
