以前列腺癌干细胞为靶点进行癌症治疗。
Targeting prostate cancer stem cells for cancer therapy.
作者信息
Wang Guocan, Wang Zhiwei, Sarkar Fazlul H, Wei Wenyi
机构信息
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
出版信息
Discov Med. 2012 Feb;13(69):135-42.
Abstract
Prostate cancer is the most common malignant neoplasm in men and the second most frequent cause of cancer death for males in the United States. Recently, emerging evidence suggests that prostate cancer stem cells (CSCs) may play a critical role in the development and progression of prostate cancer. Therefore, targeting prostate CSCs for the prevention of tumor progression and treatment of prostate cancer could become a novel strategy for better treatment of patients diagnosed with prostate cancer. In this review article, we will summarize the most recent advances in the prostate CSCs field, with particular emphasis on targeting prostate CSCs to treat prostate cancer.
摘要
前列腺癌是男性中最常见的恶性肿瘤，也是美国男性癌症死亡的第二大常见原因。最近，新出现的证据表明，前列腺癌干细胞（CSCs）可能在前列腺癌的发生和发展中起关键作用。因此，针对前列腺癌干细胞来预防肿瘤进展和治疗前列腺癌，可能成为一种更好地治疗前列腺癌患者的新策略。在这篇综述文章中，我们将总结前列腺癌干细胞领域的最新进展，特别强调针对前列腺癌干细胞来治疗前列腺癌。
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