First Department of Medicine, Hokkaido University School of Medicine, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Allergy Asthma Proc. 2012 Jan-Feb;33(1):90-4. doi: 10.2500/aap.2012.33.3491.
To date, two studies have reported lower total serum immunoglobulin E (IgE) levels and lower prevalence of atopy in patients with sarcoidosis compared with healthy subjects. However, those reports did not consider age or gender differences between cases and controls. In addition, the association between total serum IgE levels and clinical manifestations of sarcoidosis has not been clarified. This study assessed total serum IgE levels and prevalence of atopy in patients with sarcoidosis after taking age and sex differences into account and evaluated associations between total serum IgE levels and clinical manifestations of sarcoidosis. Total serum IgE levels and prevalence of atopy on initial visits were compared between 189 patients with sarcoidosis and 378 age- and sex-matched controls. Associations between total serum IgE levels and involvement of each affected organ were evaluated. Changes in total serum IgE levels during the clinical course of sarcoidosis were also evaluated. Total serum IgE levels were significantly lower in patients with sarcoidosis than in controls, independent of atopic status (atopic subjects, p = 0.025; nonatopic subjects, p < 0.001). Total serum IgE levels did not differ according to the involvement of different organs. Total serum IgE levels decreased further, albeit only slightly, after disease remission (p < 0.001). Increased susceptibility to sarcoidosis may be attributable to several underlying genetic or environmental factors that result in lower total serum IgE levels.
迄今为止，已有两项研究报道，与健康受试者相比，结节病患者的总血清免疫球蛋白 E（IgE）水平较低，且过敏症的患病率较低。然而，这些报告并未考虑病例和对照组之间的年龄或性别差异。此外，总血清 IgE 水平与结节病临床表现之间的关联也尚未阐明。本研究评估了在考虑年龄和性别差异后，结节病患者的总血清 IgE 水平和过敏症患病率，并评估了总血清 IgE 水平与结节病临床表现之间的关联。在初次就诊时，比较了 189 例结节病患者和 378 例年龄和性别匹配的对照组的总血清 IgE 水平和过敏症患病率。评估了总血清 IgE 水平与每个受累器官的关系。还评估了结节病临床病程中总血清 IgE 水平的变化。无论过敏状态如何（过敏受试者，p = 0.025；非过敏受试者，p < 0.001），结节病患者的总血清 IgE 水平均明显低于对照组。总血清 IgE 水平与不同器官受累无关。尽管仅略有下降，但在疾病缓解后，总血清 IgE 水平进一步降低（p < 0.001）。结节病易感性增加可能归因于导致总血清 IgE 水平降低的多种潜在遗传或环境因素。
