Shuster S
Department of Dermatology, University of Newcastle upon Tyne, UK.
Transplant Proc. 1988 Jun;20(3 Suppl 4):19-22.
The entry of Cs into dermatology has been remarkable. It is too soon to say that the consequences will be revolutionary, but if the drug continues with its present promise and if toxicity does not prove a problem it could indeed promote a therapeutic revolution. In addition to this, Cs is likely to induce many new thoughts about possible mechanisms in dermatology and perversely in immunology, especially if it transpires that the mechanism of action of the drug is local and on an effector pathway. Thus it is too soon to predict what might be the place for Cs in dermatology. For the moment it is clear that there is an immense area in which a good deal of work has to be done to know whether the drug will fulfill its very great promise and the further prospect too that new analogues and topical preparations may take the therapeutic possibilities even further.
环孢素（Cs）进入皮肤病学领域的历程引人注目。现在就说其后果将具有革命性还为时过早，但如果这种药物能继续保持目前所展现的前景，且毒性不成问题，那么它确实可能引发一场治疗革命。除此之外，环孢素很可能会引发许多关于皮肤病学以及反常地关于免疫学中可能机制的新思考，特别是如果最终发现该药物的作用机制是局部性的且作用于效应途径。因此，现在预测环孢素在皮肤病学中的地位还为时过早。目前很明显，有一个广阔的领域，在这个领域中还需要做大量工作，以了解这种药物是否能兑现其巨大的前景，以及新的类似物和局部制剂可能进一步拓展治疗可能性的更远前景。
