Unidad de Investigación, Hospital de Jove, Avenida Eduardo Castro s/n, C.P. 33290, Gijón, Asturias, Spain.
J Clin Immunol. 2012 Aug;32(4):848-54. doi: 10.1007/s10875-012-9666-3. Epub 2012 Feb 29.
Dysregulation of toll-like receptors (TLR) signaling can result in chronic inflammatory and over-exuberant repair responses. The aim of this study was to investigate the expression and clinical relevance of TLR in colorectal polyps.
The expression levels of six TLR were analyzed in 70 patients with different histological types of colorectal polyps, 38 of which developed colorectal carcinoma (CC). These analyses were performed by real-time polymerase chain reaction, western blot, and immunohistochemistry.
TLR9 expression was higher in hyperplastic or adenomatous polyps compared to other polyp types. Hyperplastic polyps also showed increased TLR7 levels compared to the other polyp types. TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC.
Our findings suggest a possible protective role of TLR expression against malignant transformation in the colorectal mucosa. TLR may represent a pathological marker of CC risk in colorectal polyps. The role of these factors in the pathology of colorectal polyps deserves further investigation.
Toll 样受体（TLR）信号的失调可导致慢性炎症和过度活跃的修复反应。本研究旨在探讨 TLR 在结直肠息肉中的表达及其临床相关性。
通过实时聚合酶链反应、western blot 和免疫组织化学分析了 70 例不同组织学类型结直肠息肉患者（其中 38 例发展为结直肠癌[CC]）中 6 种 TLR 的表达水平。
与其他息肉类型相比，增生性或腺瘤性息肉中 TLR9 的表达更高。与其他息肉类型相比，增生性息肉中 TLR7 的水平也更高。在发展为 CC 的患者的增生性和管状绒毛状腺瘤性息肉中，TLR7 的表达较低。在发展为 CC 的患者的增生性和绒毛状息肉中，TLR9 的表达降低。
我们的研究结果表明，TLR 的表达可能对结直肠黏膜的恶性转化具有保护作用。TLR 可能是结直肠息肉中 CC 风险的病理标志物。这些因素在结直肠息肉病理中的作用值得进一步研究。
