Galeandro Aldo Innocente, Quistelli Giovanni, Scicchitano Pietro, Gesualdo Michele, Zito Annapaola, Caputo Paola, Carbonara Rosa, Galgano Giuseppe, Ciciarello Francesco, Mandolesi Sandro, Franceschi Claude, Ciccone Marco Matteo
Centro Diagnostica Globale and ASL-TA, Taranto, Italy.
Vasc Health Risk Manag. 2012;8:59-64. doi: 10.2147/VHRM.S27552. Epub 2012 Feb 7.
The study aim was to test the accuracy (intra and interobserver variability), sensitivity, and specificity of a simplified noninvasive ultrasound methodology for mapping superficial and deep veins of the lower limbs.
62 consecutive patients, aged 62 ± 11 years, were enrolled. All underwent US-examinations, performed by two different investigators, of both legs, four anatomical parts, and 17 veins, to assess the interobserver variability of evaluation of superficial and deep veins of the lower limbs.
Overall the agreement between the second versus the first operator was very high in detecting reflux (sensitivity 97.9, specificity 99.7, accuracy 99.5; P = 0.80 at McNemar test). The higher CEAP classification stages were significantly associated with reflux (odds ratio: 1.778, 95% confidence interval: 1.552-2.038; P < 0.001) as well as with thrombosis (odds ratio: 2.765, 95% confidence interval: 1.741-4.389; P < 0.001). Thus, our findings show a strict association between the symptoms of venous disorders and ultrasound evaluation results for thrombosis or reflux.
This study demonstrated that our venous mapping protocol is a reliable method showing a very low interobserver variability, which makes it accurate and reproducible for the assessment of the morphofunctional status of the lower limb veins.
本研究旨在测试一种用于绘制下肢浅静脉和深静脉的简化无创超声方法的准确性（观察者内和观察者间变异性）、敏感性和特异性。
纳入62例年龄为62±11岁的连续患者。所有患者均由两名不同的研究者对双腿的四个解剖部位和17条静脉进行超声检查，以评估下肢浅静脉和深静脉评估的观察者间变异性。
总体而言，第二位操作者与第一位操作者在检测反流方面的一致性非常高（敏感性97.9，特异性99.7，准确性99.5；McNemar检验P=0.80）。较高的CEAP分类阶段与反流显著相关（比值比：1.778，95%置信区间：1.552 - 2.038；P<0.001），也与血栓形成相关（比值比：2.765，95%置信区间：1.741 - 4.389；P<0.001）。因此，我们的研究结果表明静脉疾病症状与血栓形成或反流的超声评估结果之间存在密切关联。
本研究表明，我们的静脉造影方案是一种可靠的方法，观察者间变异性非常低，这使其在评估下肢静脉的形态功能状态时准确且可重复。
