Rejuvenating liver and pancreas through cell transdifferentiation.
作者信息
Yi Fei, Liu Guang-Hui, Izpisua Belmonte Juan Carlos
机构信息
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
出版信息
Cell Res. 2012 Apr;22(4):616-9. doi: 10.1038/cr.2012.33. Epub 2012 Feb 28.
Abstract
摘要
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Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA.使用 Pdx1、Ngn3 和 MafA 将胰腺外分泌细胞重编程为β细胞特征。
Biochem J. 2012 Mar 15;442(3):539-50. doi: 10.1042/BJ20111678.
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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.通过定义因子直接将小鼠成纤维细胞转化为肝细胞样细胞。
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Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors.通过定义因子将小鼠成纤维细胞诱导为功能性肝样细胞。
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Stem cells: The dark side of induced pluripotency.干细胞：诱导多能性的阴暗面。
Nature. 2011 Mar 3;471(7336):46-7. doi: 10.1038/471046a.
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Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.去分化、转分化和重编程：三种再生途径。
Nat Rev Mol Cell Biol. 2011 Feb;12(2):79-89. doi: 10.1038/nrm3043.
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Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.地塞米松处理诱导胰腺腺泡细胞重编程为肝细胞和胆管细胞。
PLoS One. 2010 Oct 27;5(10):e13650. doi: 10.1371/journal.pone.0013650.
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HNF-4α determines hepatic differentiation of human mesenchymal stem cells from bone marrow.HNF-4α 决定骨髓间充质干细胞向肝系细胞的分化。
World J Gastroenterol. 2010 Oct 28;16(40):5092-103. doi: 10.3748/wjg.v16.i40.5092.
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Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling.糖皮质激素依赖性胰腺祖细胞向肝细胞的转分化依赖于 WNT 信号的短暂抑制。
J Cell Sci. 2010 Jun 15;123(Pt 12):2103-10. doi: 10.1242/jcs.070722. Epub 2010 May 25.
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Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.成年胰腺α细胞在β细胞大量缺失后向β细胞的转化。
Nature. 2010 Apr 22;464(7292):1149-54. doi: 10.1038/nature08894. Epub 2010 Apr 4.
10
Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process.Exendin-4 可促进肝细胞增殖，并增强 PDX-1 诱导的肝向胰腺转分化过程。
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