Zhou Qiao, Melton Douglas A
Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, HHMI, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Cell Stem Cell. 2008 Oct 9;3(4):382-8. doi: 10.1016/j.stem.2008.09.015.
Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these two approaches with particular emphasis on the latter and its relevance for regenerative medicine.
成年哺乳动物的细胞可以被转化（重编程）为新的细胞。一种方法是将成年细胞转化为多能干细胞，然后分化以再生新的细胞类型。或者，成年细胞可以直接转化为其他成熟细胞或祖细胞。我们将讨论并比较这两种方法，特别强调后者及其与再生医学的相关性。
