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寡核苷酸模板反应在核酸检测中的应用。

Oligonucleotide-templated reactions for sensing nucleic acids.

机构信息

Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute 2-1, Hirosawa, Wako-Shi, Saitama 351-0198, Japan.

出版信息

Molecules. 2012 Feb 29;17(3):2446-63. doi: 10.3390/molecules17032446.

DOI:10.3390/molecules17032446
PMID:22374329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268776/
Abstract

Oligonucleotide-templated reactions are useful for applying nucleic acid sensing. Various chemistries for oligonucleotide-templated reaction have been reported so far. Major scientific interests are focused on the development of signal amplification systems and signal generation systems. We introduce the recent advances of oligonucleotide-templated reaction in consideration of the above two points.

摘要

寡核苷酸模板反应在核酸传感方面具有应用价值。目前已经报道了多种用于寡核苷酸模板反应的化学方法。主要的科学关注点集中在信号放大系统和信号产生系统的开发上。我们考虑到这两点，介绍了寡核苷酸模板反应的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/9779c5bc831d/molecules-17-02446-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/ae6f97d70bf5/molecules-17-02446-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/bcb74ffd8f1f/molecules-17-02446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/0f63f49b5148/molecules-17-02446-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/ab354796512b/molecules-17-02446-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/2ab76e7240c6/molecules-17-02446-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/0fe3b0eb69e0/molecules-17-02446-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/8b01829f8606/molecules-17-02446-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/63fde6d7cae3/molecules-17-02446-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/9779c5bc831d/molecules-17-02446-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/ae6f97d70bf5/molecules-17-02446-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/bcb74ffd8f1f/molecules-17-02446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/0f63f49b5148/molecules-17-02446-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/ab354796512b/molecules-17-02446-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/2ab76e7240c6/molecules-17-02446-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/0fe3b0eb69e0/molecules-17-02446-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/8b01829f8606/molecules-17-02446-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/63fde6d7cae3/molecules-17-02446-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f07/6268776/9779c5bc831d/molecules-17-02446-g009.jpg

相似文献

[1]
Oligonucleotide-templated reactions for sensing nucleic acids.

Molecules. 2012-2-29

[2]
Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: concept and biomedical applications.

Bioorg Med Chem. 2014-8-15

[3]
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[4]
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[5]
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[6]
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[7]
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[8]
Amplification-Free Detection of Circulating microRNA Biomarkers from Body Fluids Based on Fluorogenic Oligonucleotide-Templated Reaction between Engineered Peptide Nucleic Acid Probes: Application to Prostate Cancer Diagnosis.

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[9]
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[10]
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引用本文的文献

[1]
Chemical autoligation with phosphorothioate- and sulfonamide-terminated DNA via intramolecular cross-activation.

Commun Chem. 2025-8-6

[2]
Combining recombinase polymerase amplification and DNA-templated reaction for SARS-CoV-2 sensing with dual fluorescence and lateral flow assay output.

Biopolymers. 2022-4

[3]
Using antibodies to control DNA-templated chemical reactions.

Nat Commun. 2020-12-7

[4]
Shining light on clay-chromophore hybrids: layered templates for accelerated ring closure photo-oxidation.

Chem Sci. 2015-11-1

[5]
Peptide nucleic acid-templated selenocystine-selenoester ligation enables rapid miRNA detection.

Chem Sci. 2017-11-22

[6]
Kinase-templated abiotic reaction.

Chem Sci. 2017-7-1

[7]
Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA.

Chem Sci. 2015-1-1

[8]
Chemical ligation of oligonucleotides using an electrophilic phosphorothioester.

Nucleic Acids Res. 2017-7-7

[9]
Nucleic Acid Templated Reactions for Chemical Biology.

ChemMedChem. 2017-6-21

[10]
Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity.

Angew Chem Int Ed Engl. 2017-4-6

本文引用的文献

[1]
Nucleic acid templated uncaging of fluorophores using Ru-catalyzed photoreduction with visible light.

Org Lett. 2011-12-29

[2]
Template directed reversible photochemical ligation of oligodeoxynucleotides.

Molecules. 2011-12-27

[3]
Cleavage of oligonucleotides containing a P3'→N5' phosphoramidate linkage mediated by single-stranded oligonucleotide templates.

Molecules. 2011-12-20

[4]
Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers.

Bioorg Med Chem. 2011-10-20

[5]
Fluorescence detection of intron lariat RNA with reduction-triggered fluorescent probes.

Angew Chem Int Ed Engl. 2011-12-9

[6]
Nucleic acid-templated energy transfer leading to a photorelease reaction and its application to a system displaying a nonlinear response.

J Am Chem Soc. 2011-10-21

[7]
Improved templated fluorogenic probes enhance the analysis of closely related pathogenic bacteria by microscopy and flow cytometry.

Bioconjug Chem. 2011-8-26

[8]
DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides.

Bioorg Med Chem Lett. 2011-5-14

[9]
DNA-triggered synthesis and bioactivity of proapoptotic peptides.

Angew Chem Int Ed Engl. 2011-3-14

[10]
DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker.

Chem Commun (Camb). 2011-3-3

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