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Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention.低高密度脂蛋白胆固醇且甘油三酯水平正常是患有代谢综合征的西非人和非裔美国人中最常见的血脂模式:对心血管疾病预防的启示。
CVD Prev Control. 2010 Sep 1;5(3):75-80. doi: 10.1016/j.cvdpc.2010.07.003.
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Diabetes Metab. 2010 Jun;36(3):204-8. doi: 10.1016/j.diabet.2009.11.009. Epub 2010 Mar 4.
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Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.代谢综合征的协调:国际糖尿病联盟流行病学与预防特别工作组、美国国立心肺血液研究所、美国心脏协会、世界心脏联盟、国际动脉粥样硬化学会以及国际肥胖研究协会的联合中期声明
Circulation. 2009 Oct 20;120(16):1640-5. doi: 10.1161/CIRCULATIONAHA.109.192644. Epub 2009 Oct 5.
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Obesity and regional fat distribution in Kenyan populations: impact of ethnicity and urbanization.肯尼亚人群中的肥胖与局部脂肪分布:种族和城市化的影响
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肯尼亚城市人口中代谢综合征的流行情况。

Prevalence of metabolic syndrome among an urban population in Kenya.

机构信息

Centre for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya.

出版信息

Diabetes Care. 2012 Apr;35(4):887-93. doi: 10.2337/dc11-0537. Epub 2012 Feb 28.

DOI:10.2337/dc11-0537
PMID:22374643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3308294/
Abstract

OBJECTIVE

Developing countries are undergoing an epidemiologic transition accompanied by increasing burden of cardiovascular disease (CVD) linked to urbanization and lifestyle modifications. Metabolic syndrome is a cluster of CVD risk factors whose extent in Kenya remains unknown. The aim of this study was to determine the prevalence of metabolic syndrome and factors associated with its occurrence among an urban population in Kenya.

RESEARCH DESIGN AND METHODS

This was a household cross-sectional survey comprising 539 adults (aged ≥18 years) living in Nairobi, drawn from 30 clusters across five socioeconomic classes. Measurements included waist circumference, HDL cholesterol, triacylglycerides (TAGs), fasting glucose, and blood pressure.

RESULTS

The prevalence of metabolic syndrome was 34.6% and was higher in women than in men (40.2 vs. 29%; P < 0.001). The most frequently observed features were raised blood pressure, a higher waist circumference, and low HDL cholesterol (men: 96.2, 80.8, and 80%; women: 89.8, 97.2, and 96.3%, respectively), whereas raised fasting glucose and TAGs were observed less frequently (men: 26.9 and 63.3%; women: 26.9 and 30.6%, respectively). The main factors associated with the presence of metabolic syndrome were increasing age, socioeconomic status, and education.

CONCLUSIONS

Metabolic syndrome is prevalent in this urban population, especially among women, but the incidence of individual factors suggests that poor glycemic control is not the major contributor. Longitudinal studies are required to establish true causes of metabolic syndrome in Kenya. The Kenyan government needs to create awareness, develop prevention strategies, and strengthen the health care system to accommodate screening and management of CVDs.

摘要

目的

发展中国家正经历着与城市化和生活方式改变相关的心血管疾病(CVD)负担增加的流行病学转变。代谢综合征是一组 CVD 风险因素,其在肯尼亚的严重程度尚不清楚。本研究旨在确定代谢综合征在肯尼亚城市人口中的流行程度及其相关因素。

研究设计与方法

这是一项家庭横断面调查,包括来自内罗毕 30 个集群的 539 名(年龄≥18 岁)成年人,来自五个社会经济阶层。测量包括腰围、高密度脂蛋白胆固醇(HDL 胆固醇)、三酰甘油(TAGs)、空腹血糖和血压。

结果

代谢综合征的患病率为 34.6%,女性高于男性(40.2%比 29%;P<0.001)。最常见的表现是血压升高、腰围增大和 HDL 胆固醇降低(男性:96.2%、80.8%和 80%;女性:89.8%、97.2%和 96.3%),而空腹血糖和 TAGs 升高则不太常见(男性:26.9%和 63.3%;女性:26.9%和 30.6%)。与代谢综合征存在相关的主要因素是年龄增长、社会经济地位和教育程度。

结论

代谢综合征在该城市人群中很普遍,尤其是在女性中,但个别因素的发生率表明,血糖控制不佳不是主要原因。需要进行纵向研究以确定代谢综合征在肯尼亚的真正原因。肯尼亚政府需要提高认识、制定预防策略,并加强卫生保健系统,以适应 CVD 的筛查和管理。