Hussain Hidayat, Hussain Javid, Ali Samina, Al-Harrasi Ahmed, Saleem Muhammad, Miana Ghulam Abbas, Riaz Muhammad, Anwar Saeed, Hussain Sajjad, Ali Liaqat
Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Sultanate of Oman.
J Asian Nat Prod Res. 2012;14(4):297-300. doi: 10.1080/10286020.2011.652953.
Two new benzo-isochromenes, named cichorins B (1) and C (2), were isolated from Cichorium intybus. The structures of the new compounds were elucidated by detailed spectroscopic analysis such as ¹H, ¹³C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Relative configurations of asymmetric centers of cichorins B and C were determined by the analysis of the ¹H NMR coupling constants together with the 2D NOESY and 1D NOE experiments as well as from [α]²⁵(D) value.
从菊苣中分离出两种新的苯并异色烯，命名为菊苣素B（1）和菊苣素C（2）。通过¹H、¹³C NMR、COSY、HMQC、HMBC和HR-EI-MS等详细的光谱分析确定了新化合物的结构。通过¹H NMR耦合常数分析以及二维NOESY和一维NOE实验，并结合[α]²⁵(D)值，确定了菊苣素B和C不对称中心的相对构型。
