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钯介导的多米诺反应：在水介质中合成异色烯

Palladium mediated domino reaction: synthesis of isochromenes under aqueous medium.

作者信息

Punia Lavisha, Ramesh Karu, Satyanarayana Gedu

机构信息

Department of Chemistry, Indian Institute of Technology (IIT) Hyderabad Kandi - 502 285, Sangareddy District Telangana India

出版信息

RSC Adv. 2020 Jan 2;10(1):338-349. doi: 10.1039/c9ra08792c. eCollection 2019 Dec 20.

DOI:10.1039/c9ra08792c
PMID:35492569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9047682/
Abstract

Isochromenes have been synthesized using palladium-catalyzed C-C and C-O bond forming reactions starting from -bromo tertiary benzylic alcohols and internal acetylenes. Notably, this domino process is feasible by using the green solvent, water. The protocol exhibited a broad substrate scope and afforded various isochromenes.

摘要

异色烯是通过钯催化的碳-碳和碳-氧键形成反应，以β-溴代叔苄醇和内乙炔为起始原料合成的。值得注意的是，这种多米诺过程在使用绿色溶剂水时是可行的。该方法具有广泛的底物范围，并能提供各种异色烯。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b412/9047682/3ed18890f586/c9ra08792c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b412/9047682/aae0c7b12d69/c9ra08792c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b412/9047682/3ed18890f586/c9ra08792c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b412/9047682/aae0c7b12d69/c9ra08792c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b412/9047682/3ed18890f586/c9ra08792c-s1.jpg

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