Satmbekova Dinara, Srivedavyasasri Radhakrishnan, Orazbekov Yerkebulan, Omarova Roza, Datkhayev Ubaidilla, Ross Samir A
a Department of Pharmacy , Asfendiyarov Kazakh National Medical University , Almaty , Republic of Kazakhstan.
b National Center for Natural Product Research , University of Mississippi , University , MS , USA.
Nat Prod Res. 2018 Jun;32(11):1343-1347. doi: 10.1080/14786419.2017.1343319. Epub 2017 Jun 19.
Cichorium intybus L. (Asteraceae family) is a world-wide grown plant known as chicory. In traditional medicine, this plant is used as diuretic, anti-inflammatory, digestive, cardiotonic and liver tonic. Chromatographic purification of the supercritical fluid extract of aerial parts of C. intybus on silica gel column led to isolation of three compounds: new compound, 28β-hydroxytaraxasterol (I), and two known compounds usnic acid (II) and β-sitosterol (III). Purification of the ethanolic extract of aerial parts of this plant on silica gel column chromatography yielded four compounds: 1,3-dioleylglycerate (IV), sitoindoside II (V), 11β-13-dihydrolactucin (VI) and β-sitosterol-3-O-glucoside (VII). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding, as well as antibacterial, antifungal and antimalarial activities. Compound I showed moderate activity (60.5% displacement) towards CB1 receptor.
菊苣（菊科）是一种在全球范围内种植的植物，被称为苦苣。在传统医学中，这种植物被用作利尿剂、抗炎药、助消化药、强心剂和肝脏滋补剂。对菊苣地上部分的超临界流体提取物在硅胶柱上进行色谱纯化，得到了三种化合物：新化合物28β-羟基蒲公英甾醇（I），以及两种已知化合物松萝酸（II）和β-谷甾醇（III）。对该植物地上部分的乙醇提取物在硅胶柱色谱上进行纯化，得到了四种化合物：1,3-二油酰甘油（IV）、水飞蓟宾糖苷II（V）、11β-13-二氢莴苣素（VI）和β-谷甾醇-3-O-葡萄糖苷（VII）。通过一维、二维核磁共振和质谱光谱数据确定了分离出的化合物的结构。对所有馏分和分离出的化合物进行了大麻素和阿片受体结合测试，以及抗菌、抗真菌和抗疟活性测试。化合物I对CB1受体表现出中等活性（60.5%置换率）。
