Charlemagne D, Léger J, Schwartz K, Geny B, Zachowski A, Lelièvre L
C R Seances Acad Sci D. 1979 Mar 19;288(11):963-6.
EDTA treatment of isolated plasma membranes from MF2S cells increased 1,000 fold the sensitivity of (Na+ + K+) ATPase activity to ouabain. The original sensitivity of the enzyme to the drug is recovered after addition of tropomyosin together with Ca++ ions to the treated membranes.
用乙二胺四乙酸(EDTA)处理MF2S细胞分离出的质膜,可使(钠+钾)ATP酶活性对哇巴因的敏感性提高1000倍。在处理过的膜中加入原肌球蛋白和钙离子后,该酶对药物的原始敏感性得以恢复。