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[原肌球蛋白在(钠 + 钾)ATP 酶对哇巴因敏感性中的作用]

[Role of tropomyosin in the sensitivity of (Na+ + K+) ATPase to ouabain].

作者信息

Charlemagne D, Léger J, Schwartz K, Geny B, Zachowski A, Lelièvre L

出版信息

C R Seances Acad Sci D. 1979 Mar 19;288(11):963-6.

PMID:223773
Abstract

EDTA treatment of isolated plasma membranes from MF2S cells increased 1,000 fold the sensitivity of (Na+ + K+) ATPase activity to ouabain. The original sensitivity of the enzyme to the drug is recovered after addition of tropomyosin together with Ca++ ions to the treated membranes.

摘要

用乙二胺四乙酸(EDTA)处理MF2S细胞分离出的质膜,可使(钠+钾)ATP酶活性对哇巴因的敏感性提高1000倍。在处理过的膜中加入原肌球蛋白和钙离子后,该酶对药物的原始敏感性得以恢复。

相似文献

1
[Role of tropomyosin in the sensitivity of (Na+ + K+) ATPase to ouabain].[原肌球蛋白在(钠 + 钾)ATP 酶对哇巴因敏感性中的作用]
C R Seances Acad Sci D. 1979 Mar 19;288(11):963-6.
2
[Purification of a membrane protein modifying the sensitivity of Na+/K+ ATPase to ouabain from a supernatant of plasma membrane treated with EDTA].[从经乙二胺四乙酸(EDTA)处理的质膜上清液中纯化一种可改变钠钾ATP酶对哇巴因敏感性的膜蛋白]
C R Seances Acad Sci D. 1979 Nov 26;289(14):1057-60.
3
[Purification from a total cellular lysate of a protein modifying the sensitivity of Na+/K+ ATPase to ouabain].[从一种可改变钠钾ATP酶对哇巴因敏感性的蛋白质的全细胞裂解物中进行纯化]
C R Seances Acad Sci D. 1979 Dec 10;289(15):1137-40.
4
Involvement of tropomyosin in the sensitivity of Na+ + K+ ATPase to ouabain.
Biochem Pharmacol. 1980 Feb;29(3):297-300. doi: 10.1016/0006-2952(80)90503-1.
5
Ouabain-resistant (Na+,K+)-ATPase enzyme activity in chemically induced ouabain-resistant C3H/10T1/2 cells.化学诱导的哇巴因抗性C3H/10T1/2细胞中对哇巴因耐药的(钠,钾)-ATP酶活性
Mol Toxicol. 1989 Apr-Jun;2(2):75-98.
6
Specific involvement of calmodulin and non-specific effect of tropomyosin in the sensitivity to ouabain of Na+,K+-ATPase in murine plasmocytoma cells.
Eur J Biochem. 1985 Apr 1;148(1):13-9. doi: 10.1111/j.1432-1033.1985.tb08800.x.
7
Inhibition of (Na+ + K+)-ATPase by ouabain: involvement of calcium and membrane proteins.
Biochim Biophys Acta. 1979 Nov 2;557(2):399-408. doi: 10.1016/0005-2736(79)90338-9.
8
Nonpolar amino acid substitutions of potential cation binding residues glu-955 and glu-956 of the rat alpha 1 isoform of Na+, K(+)-ATPase.大鼠Na + ,K(+)-ATP酶α1同工型潜在阳离子结合残基Glu-955和Glu-956的非极性氨基酸取代。
Cell Mol Biol Res. 1993;39(5):497-507.
9
Ouabain insensitive Na+-stimulated ATPase activity associated to basal-lateral plasma membranes of rat kidney cells.哇巴因不敏感的、与大鼠肾细胞基底外侧质膜相关的钠刺激的ATP酶活性。
Acta Cient Venez. 1983;34(5-6):322-8.
10
Functional consequences of substitutions of the carboxyl residue glutamate 779 of the Na,K-ATPase.钠钾ATP酶羧基残基谷氨酸779替代的功能后果。
Cell Mol Biol Res. 1995;41(1):29-37.

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