Department of Life Science, Meiji University, Higashimita Tama-ku, Kawasaki, Japan.
Eur J Dermatol. 2012 Mar-Apr;22(2):211-7. doi: 10.1684/ejd.2011.1618.
The purpose of this study was to evaluate the effects of oral administration of Butyrivibrio fibrisolvens MDT-1 (MDT-1) on mite antigen-induced atopic dermatitis (AD) in NC/Nga mice. When administration of the freeze-dried cells of MDT-1 was initiated one week before mite-antigen swabbing, the development of AD-like skin lesions was alleviated. The cell homogenate and membrane fraction had similar effects, showing that cell components are effective. Freeze-dried cells were found to be replaceable by the crude lipopolysaccharide extracted from MDT-1. Alleviation of AD was concomitant with a decrease in the serum IgE level. Determination of cytokines produced by Peyer's patch cells showed that MDT-1 administration increased IL-12, tended to increase IFN-γ, and tended to decrease IL-10, but did not affect IL-4. When MDT-1 was administered after the skin lesions had progressed, the symptoms were ameliorated, suggesting that MDT-1 has AD-healing effects. MDT-1 was as effective as prednisolone, but different from prednisolone in that MDT-1 showed no detectable side effects such as body weight loss. We previously reported that MDT-1 administration prevented and alleviated colorectal cancer, sarcoma, and enterocolitis in mice. Taken together, MDT-1 might be beneficial for maintaining the health of pet animals and humans.
本研究旨在评估口服丁酸梭菌 MDT-1（MDT-1）对 NC/Nga 小鼠螨抗原诱导的特应性皮炎（AD）的影响。当在螨抗原涂抹前一周开始给予 MDT-1 的冻干细胞时，AD 样皮肤损伤的发展得到缓解。细胞匀浆和膜部分具有相似的效果，表明细胞成分是有效的。发现冻干细胞可被从 MDT-1 中提取的粗脂多糖替代。AD 的缓解伴随着血清 IgE 水平的降低。对派尔集合淋巴结细胞产生的细胞因子的测定表明，MDT-1 给药增加了 IL-12，倾向于增加 IFN-γ，并且倾向于降低 IL-10，但不影响 IL-4。当在皮肤损伤进展后给予 MDT-1 时，症状得到改善，表明 MDT-1 具有 AD 愈合作用。MDT-1 与泼尼松龙一样有效，但与泼尼松龙不同的是，MDT-1 没有表现出可检测到的副作用，如体重减轻。我们之前报道过 MDT-1 给药可预防和缓解小鼠的结直肠癌、肉瘤和肠炎。综上所述，MDT-1 可能有益于维持宠物动物和人类的健康。
