• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block.

作者信息

Cao Sheng, Wang Yibin, Peng Xiaohua

机构信息

Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, 3210 N. Cramer St., Milwaukee, WI 53211, USA.

出版信息

Chemistry. 2012 Mar 26;18(13):3850-4. doi: 10.1002/chem.201200075. Epub 2012 Feb 29.

DOI:10.1002/chem.201200075
PMID:22378607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3535311/
Abstract
摘要

相似文献

1
ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block.活性氧诱导型DNA交联剂作为一种新型抗癌前药构建单元。
Chemistry. 2012 Mar 26;18(13):3850-4. doi: 10.1002/chem.201200075. Epub 2012 Feb 29.
2
Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.过氧化氢诱导的 DNA 交联剂：靶向抗癌前药。
J Am Chem Soc. 2011 Dec 7;133(48):19278-81. doi: 10.1021/ja2073824. Epub 2011 Nov 10.
3
Reactive oxygen species (ROS) inducible DNA cross-linking agents and their effect on cancer cells and normal lymphocytes.活性氧（ROS）诱导的 DNA 交联剂及其对癌细胞和正常淋巴细胞的影响。
J Med Chem. 2014 Jun 12;57(11):4498-510. doi: 10.1021/jm401349g. Epub 2014 May 16.
4
Amonafide-based HO-responsive theranostic prodrugs: Exploring the correlation between HO level and anticancer efficacy.基于阿霉素的 HO 响应型治疗前药物：探究 HO 水平与抗癌疗效之间的相关性。
Bioorg Chem. 2024 Sep;150:107560. doi: 10.1016/j.bioorg.2024.107560. Epub 2024 Jun 12.
5
Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).源自苯酚和苯胺氮芥的烷化剂前药的优化：一种用于抗体导向酶前药疗法（ADEPT）的新型临床候选前药（ZD2767）。
J Med Chem. 1995 Dec 22;38(26):5051-65. doi: 10.1021/jm00026a013.
6
Boronic acid/boronate prodrugs for cancer treatment: current status and perspectives.用于癌症治疗的硼酸/硼酸盐前药：现状与展望
Future Med Chem. 2021 May;13(10):859-861. doi: 10.4155/fmc-2021-0037. Epub 2021 Apr 13.
7
Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response.具有 Cu(ii)介导的芬顿反应增强的 ROS 响应的治疗性亚氨基硼酸酯基聚合物囊泡。
Chem Commun (Camb). 2020 Oct 18;56(81):12246-12249. doi: 10.1039/d0cc03607b. Epub 2020 Sep 15.
8
Aminoferrocene-based prodrugs activated by reactive oxygen species.基于氨基酸的前药，通过活性氧物质激活。
J Med Chem. 2012 Jan 26;55(2):924-34. doi: 10.1021/jm2014937. Epub 2012 Jan 11.
9
The leaving group strongly affects H₂O₂-induced DNA cross-linking by arylboronates.离去基团对芳基硼酸酯引发的H₂O₂诱导的DNA交联有强烈影响。
J Org Chem. 2014 Jan 17;79(2):501-8. doi: 10.1021/jo401901x. Epub 2014 Jan 6.
10
Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent.
J Am Chem Soc. 2001 May 23;123(20):4865-6. doi: 10.1021/ja005658r.

引用本文的文献

1
Supramolecular Materials and Strategies for Bioorthogonal Chemical Transformations.用于生物正交化学转化的超分子材料与策略
Chem Rev. 2025 Aug 13;125(15):7223-7274. doi: 10.1021/acs.chemrev.5c00047. Epub 2025 Aug 1.
2
Detection and Analysis of Reactive Oxygen Species (ROS): Buffer Components Are Not Bystanders.活性氧（ROS）的检测与分析：缓冲液成分并非旁观者
Anal Chem. 2025 Jul 22;97(28):14931-14942. doi: 10.1021/acs.analchem.4c07070. Epub 2025 Jun 3.
3
Thioether Oxidation Chemistry in Reactive Oxygen Species (ROS)-Sensitive Trigger Design: A Kinetic Analysis.

本文引用的文献

1
Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.过氧化氢诱导的 DNA 交联剂：靶向抗癌前药。
J Am Chem Soc. 2011 Dec 7;133(48):19278-81. doi: 10.1021/ja2073824. Epub 2011 Nov 10.
2
A unique paradigm for a Turn-ON near-infrared cyanine-based probe: noninvasive intravital optical imaging of hydrogen peroxide.一种独特的近红外花菁类探针“开启”模式：用于过氧化氢的非侵入性活体光学成像。
J Am Chem Soc. 2011 Jul 20;133(28):10960-5. doi: 10.1021/ja203145v. Epub 2011 Jun 22.
3
Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents.
活性氧（ROS）敏感触发设计中的硫醚氧化化学：动力学分析
Org Lett. 2025 Mar 28;27(12):3071-3076. doi: 10.1021/acs.orglett.5c00747. Epub 2025 Mar 19.
4
Boronate-Based Bioactive Compounds Activated by Peroxynitrite and Hydrogen Peroxide.由过氧亚硝酸盐和过氧化氢激活的基于硼酸盐的生物活性化合物。
Redox Biochem Chem. 2024 Dec;10. doi: 10.1016/j.rbc.2024.100040. Epub 2024 Aug 14.
5
A critical factor in reactive oxygen species (ROS) studies: the need to understand the chemistry of the solvent used: the case of DMSO.活性氧（ROS）研究中的一个关键因素：需要了解所用溶剂的化学性质：以二甲基亚砜（DMSO）为例。
Chem Sci. 2024 Oct 8;15(43):17843-51. doi: 10.1039/d4sc05038j.
6
Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)-Sensitive Triggers.定量因素在活性氧（ROS）敏感触发物可行性分析中的引入。
Angew Chem Int Ed Engl. 2024 Jun 21;63(26):e202403880. doi: 10.1002/anie.202403880. Epub 2024 Jun 3.
7
Coumarin Based Fluorescent Probe for Detecting Heavy Metal Ions.用于检测重金属离子的香豆素基荧光探针。
J Fluoresc. 2024 Jul;34(4):1453-1483. doi: 10.1007/s10895-023-03372-3. Epub 2023 Aug 15.
8
Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers.作为放射增敏剂影响线粒体的活性氧细胞内放大器
Cancers (Basel). 2021 Dec 31;14(1):208. doi: 10.3390/cancers14010208.
9
Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer.吡喃葡萄糖基共轭苄基衍生物作为新型结肠癌选择性细胞毒剂的合成及药理学特性研究
R Soc Open Sci. 2021 Feb 24;8(2):201642. doi: 10.1098/rsos.201642.
10
Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer.评估苯基硼酸氮芥作为三阴性乳腺癌有效且选择性候选药物的情况。
ACS Pharmacol Transl Sci. 2021 Mar 7;4(2):687-702. doi: 10.1021/acsptsci.0c00092. eCollection 2021 Apr 9.
萘醌亚甲基作为嘌呤选择性 DNA 烷化剂的光致生成和反应性。
J Am Chem Soc. 2010 Oct 20;132(41):14625-37. doi: 10.1021/ja1063857.
4
Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach.过氧化氢激活的基质金属蛋白酶抑制剂：一种前药方法。
Angew Chem Int Ed Engl. 2010 Sep 10;49(38):6795-7. doi: 10.1002/anie.201003819.
5
Dynamic cross-linking is retained in duplex DNA after multiple exchange of strands.在多次链交换后，双链DNA中仍保留动态交联。
Angew Chem Int Ed Engl. 2010 Aug 9;49(34):5957-60. doi: 10.1002/anie.201001597.
6
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.醌甲基化物与萘二酰亚胺连接作为选择性 G-四链体烷化剂。
J Am Chem Soc. 2009 Sep 16;131(36):13132-41. doi: 10.1021/ja904876q.
7
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?通过活性氧介导的机制靶向癌细胞：一种激进的治疗方法？
Nat Rev Drug Discov. 2009 Jul;8(7):579-91. doi: 10.1038/nrd2803. Epub 2009 May 29.
8
Protein binding has a large effect on radical mediated DNA damage.蛋白质结合对自由基介导的DNA损伤有很大影响。
J Am Chem Soc. 2008 Oct 1;130(39):12890-1. doi: 10.1021/ja805440v. Epub 2008 Sep 9.
9
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines.修饰嘧啶在双链和三链DNA中形成链间交联。
J Am Chem Soc. 2008 Aug 6;130(31):10299-306. doi: 10.1021/ja802177u. Epub 2008 Jul 12.
10
A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.一种用于对活细胞线粒体中的过氧化氢进行成像的可靶向荧光探针。
J Am Chem Soc. 2008 Jul 30;130(30):9638-9. doi: 10.1021/ja802355u. Epub 2008 Jul 8.