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J Mol Biol. 2008 Nov 14;383(3):529-38. doi: 10.1016/j.jmb.2008.08.082. Epub 2008 Sep 9.
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Initial location of the RNA-dependent RNA polymerase in the bacteriophage Phi6 procapsid determined by cryo-electron microscopy.通过冷冻电子显微镜确定噬菌体Phi6原衣壳中RNA依赖性RNA聚合酶的初始位置。
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Bacteriophage phi6: a Lipid-Containing Virus of Pseudomonas phaseolicola.噬菌体phi6：一种含脂质的菜豆假单胞菌病毒。
J Virol. 1973 May;11(5):799-805. doi: 10.1128/JVI.11.5.799-805.1973.
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Structure of the bacteriophage phi6 nucleocapsid suggests a mechanism for sequential RNA packaging.噬菌体phi6核衣壳的结构提示了一种连续RNA包装的机制。
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RNA packaging device of double-stranded RNA bacteriophages, possibly as simple as hexamer of P4 protein.双链RNA噬菌体的RNA包装装置，可能简单至P4蛋白的六聚体。
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噬菌体 φ6 衣壳表面蛋白 8 与含有主要包膜蛋白 9 的病毒特异性膜泡相互作用。

Bacteriophage ϕ6 nucleocapsid surface protein 8 interacts with virus-specific membrane vesicles containing major envelope protein 9.

机构信息

Department of Biosciences, University of Helsinki, Biocenter 2, Helsinki, Finland.

出版信息

J Virol. 2012 May;86(9):5376-9. doi: 10.1128/JVI.00172-12. Epub 2012 Feb 29.

DOI:10.1128/JVI.00172-12
PMID:22379079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3347372/
Abstract

Enveloped double-stranded RNA (dsRNA) bacterial virus Pseudomonas phage ϕ6 has been developed into an advanced assembly system where purified virion proteins and genome segments self-assemble into infectious viral particles, inferring the assembly pathway. The most intriguing step is the membrane assembly occurring inside the bacterial cell. Here, we demonstrate that the middle virion shell, made of protein 8, associates with the expanded viral core particle and the virus-specific membrane vesicle.

摘要

包膜双链 RNA (dsRNA) 细菌病毒假单胞菌噬菌体 ϕ6 已被开发成为一种高级组装系统，其中纯化的病毒蛋白和基因组片段可自行组装成感染性病毒颗粒，推断出组装途径。最有趣的步骤是在细菌细胞内发生的膜组装。在这里，我们证明了由蛋白 8 组成的中间病毒壳与扩展的病毒核心颗粒和病毒特异性膜囊泡结合。