Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria.
Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria.
Int J Mol Sci. 2018 Mar 9;19(3):790. doi: 10.3390/ijms19030790.
For three decades now, ionic liquids (ILs), organic salts comprising only ions, have emerged as a new class of pharmaceuticals. Although recognition of the antimicrobial effects of ILs is growing rapidly, there is almost nothing known about their possible virucidal activities. This probably reflects the paucity of understanding virus inactivation. In this study, we performed a systematic analysis to determine the effect of specific structural motifs of ILs on three different biological test systems (viruses, bacteria and enzymes). Overall, the effects of 27 different ILs on two non-enveloped and one enveloped virus (P100, MS2 and Phi6), two Gram negative and one Gram positive bacteria (, and ) and one enzyme (Taq DNA polymerase) were investigated. Results show that while some ILs were virucidal, no clear structure activity relationships (SARs) could be identified for the non-enveloped viruses P100 and MS2. However, for the first time, a correlation has been demonstrated between the effects of ILs on enveloped viruses, bacteria and enzyme inhibition. These identified SARs serve as a sound starting point for further studies.
三十年来，离子液体（ILs）作为一类新型药物，已逐渐崭露头角。尽管人们对 ILs 的抗菌效果的认识迅速提高，但对于其潜在的抗病毒活性却几乎一无所知。这可能反映出对病毒失活机制的理解不足。在这项研究中，我们进行了系统分析，以确定 ILs 的特定结构基序对三种不同生物测试系统（病毒、细菌和酶）的影响。总体而言，我们研究了 27 种不同 ILs 对两种非包膜病毒（P100 和 MS2）和一种包膜病毒（Phi6）、两种革兰氏阴性菌（和）和一种酶（Taq DNA 聚合酶）的影响。结果表明，虽然一些 ILs 具有抗病毒活性，但对于非包膜病毒 P100 和 MS2，并未确定出明确的结构活性关系（SARs）。然而，我们首次证明了 ILs 对包膜病毒、细菌和酶抑制的作用之间存在相关性。这些确定的 SAR 为进一步的研究提供了良好的起点。
