System Medical Biology Laboratory, School of Advanced Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Int J Hematol. 2012 Mar;95(3):227-31. doi: 10.1007/s12185-012-1027-8. Epub 2012 Mar 3.
Many people believe that hematopoietic stem cell transplantation (HSCT) together with various hematopoietic factors may aid or rescue victims of acute radiation exposure. However, nearly all patients who have received current HSCT for severe bone marrow damage in the past died relatively shortly after transplantation, even when engraftment followed by autologous blood cell recovery was observed. The causes of death in such cases involved rapidly progressing insults to many non-hematopoietic tissues, such as lung and gut, potentially exacerbated by the conditioning regimen and immune dysfunction. We should recognize that at present avoiding high-dose radiation exposure is the only safe option.
许多人认为造血干细胞移植（HSCT）与各种造血因子一起可能有助于或抢救急性辐射暴露的受害者。然而，过去几乎所有因严重骨髓损伤而接受过当前 HSCT 的患者在移植后相对较短的时间内死亡，即使观察到植入和自体血细胞恢复。在这种情况下，死亡的原因涉及许多非造血组织（如肺和肠道）的迅速进展性损伤，这可能因预处理方案和免疫功能障碍而加剧。我们应该认识到，目前避免高剂量辐射暴露是唯一安全的选择。
