炎症模型：角叉菜胶或完全弗氏佐剂（CFA）诱导的大鼠水肿和超敏反应。
Models of inflammation: Carrageenan- or complete Freund's Adjuvant (CFA)-induced edema and hypersensitivity in the rat.
作者信息
Fehrenbacher Jill C, Vasko Michael R, Duarte Djane B
机构信息
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.4. doi: 10.1002/0471141755.ph0504s56.
Abstract
Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. This unit details methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections of either the footpad or vibrissal pad are described. In this manner, cutaneous inflammation can be assessed in tissue innervated by the lumbar dorsal root ganglion neurons (footpad) and by the trigeminal ganglion neurons (vibrissal pad).
摘要
炎症动物模型用于评估炎症部位炎症介质的产生、非甾体抗炎药（NSAIDs）等药物的抗炎特性，以及假定的镇痛化合物逆转皮肤超敏反应的功效。本单元详细介绍了引发和测量角叉菜胶和完全弗氏佐剂（CFA）诱导的皮肤炎症的方法。由于背根感觉系统和三叉神经感觉系统之间可能存在差异，因此描述了足垫或触须垫注射方法。通过这种方式，可以在由腰背根神经节神经元（足垫）和三叉神经节神经元（触须垫）支配的组织中评估皮肤炎症。
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本文引用的文献
1
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.通过使 CRMP-2 与突触前 Ca²⁺ 通道复合物解偶联来抑制炎症和神经性疼痛。
Nat Med. 2011 Jun 5;17(7):822-9. doi: 10.1038/nm.2345.
2
Global gene expression analysis in the mouse brainstem after hyperalgesia induced by facial carrageenan injection--evidence for a form of neurovascular coupling?面部注射角叉菜胶诱导痛觉过敏后小鼠脑干的全基因表达分析——一种神经血管耦合形式的证据？
Pain. 2009 Mar;142(1-2):133-41. doi: 10.1016/j.pain.2008.12.029. Epub 2009 Jan 23.
3
Activation of spinal microglia in a murine model of peripheral inflammation-induced, long-lasting contralateral allodynia.在外周炎症诱导的、持久的对侧痛觉过敏小鼠模型中脊髓小胶质细胞的激活。
Neurosci Lett. 2008 Jul 25;440(1):63-7. doi: 10.1016/j.neulet.2008.05.044. Epub 2008 May 17.
4
Treatment of experimental arthritis with M2000, a novel designed non-steroidal anti-inflammatory drug.用新型设计的非甾体抗炎药M2000治疗实验性关节炎。
Scand J Immunol. 2005 May;61(5):435-41. doi: 10.1111/j.1365-3083.2005.01594.x.
5
Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats.电针联合吲哚美辛增强炎性大鼠的抗痛觉过敏作用。
Pharmacol Biochem Behav. 2004 Aug;78(4):793-7. doi: 10.1016/j.pbb.2004.05.010.
6
Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat.酸樱桃花青素可抑制大鼠炎症诱导的疼痛行为。
Behav Brain Res. 2004 Aug 12;153(1):181-8. doi: 10.1016/j.bbr.2003.11.011.
7
An electronic pressure-meter nociception paw test for mice.一种用于小鼠的电子压力计伤害性爪试验。
Braz J Med Biol Res. 2004 Mar;37(3):401-7. doi: 10.1590/s0100-879x2004000300018. Epub 2004 Mar 3.
8
Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.角叉菜胶诱导大鼠后爪水肿作为抗炎药物的一种测定方法。
Proc Soc Exp Biol Med. 1962 Dec;111:544-7. doi: 10.3181/00379727-111-27849.
9
A method for measurement of analgesic activity on inflamed tissue.一种测量对炎症组织镇痛活性的方法。
Arch Int Pharmacodyn Ther. 1957 Sep 1;111(4):409-19.
10
Institutional Policies and Guidelines on Adjuvants and Antibody Production.
ILAR J. 1995;37(3):141-152. doi: 10.1093/ilar.37.3.141.
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