Department of Mechanical Engineering, Polytechnique Montréal, Montréal, QC H3T 1J4, Canada.
Qeen BioTechnologies, Gatineau, QC J9J 3K3, Canada.
Int J Mol Sci. 2024 May 28;25(11):5858. doi: 10.3390/ijms25115858.
The emerging field of nanotechnology has paved the way for revolutionary advancements in drug delivery systems, with nanosystems emerging as a promising avenue for enhancing the therapeutic potential and the stability of various bioactive compounds. Among these, cannabidiol (CBD), the non-psychotropic compound of the plant, has gained attention for its therapeutic properties. Consequently, researchers have devoted significant efforts to unlock the full potential of CBD's clinical benefits, where various nanosystems and excipients have emerged to overcome challenges associated with its bioavailability, stability, and controlled release for its transdermal application. Therefore, this comprehensive review aims to explain CBD's role in managing acute inflammatory pain and offers an overview of the state of the art of existing delivery systems and excipients for CBD. To summarize this review, a summary of the cannabinoids and therapeutical targets of CBD will be discussed, followed by its conventional modes of administration. The transdermal route of administration and the current topical and transdermal delivery systems will also be reviewed. This review will conclude with an overview of in vivo techniques that allow the evaluation of the anti-inflammatory and analgesic potentials of these systems.
新兴的纳米技术领域为药物传递系统的革命性进步铺平了道路，纳米系统作为增强各种生物活性化合物的治疗潜力和稳定性的有前途的途径而出现。在这些化合物中，大麻二酚 (CBD)，植物的非精神活性化合物，因其治疗特性而受到关注。因此，研究人员投入了大量精力来挖掘 CBD 临床效益的全部潜力，各种纳米系统和赋形剂已经出现，以克服与生物利用度、稳定性和经皮应用的控制释放相关的挑战。因此，本综述旨在解释 CBD 在管理急性炎症性疼痛中的作用，并概述 CBD 现有传递系统和赋形剂的最新技术状态。为了总结这篇综述，将讨论大麻素和 CBD 的治疗靶点及其常规给药方式。还将回顾经皮给药途径以及当前的局部和经皮给药系统。本综述将概述允许评估这些系统的抗炎和镇痛潜力的体内技术。
