炎症模型：角叉菜胶气囊肿
Models of inflammation: carrageenan air pouch.
作者信息
Duarte Djane B, Vasko Michael R, Fehrenbacher Jill C
机构信息
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.
出版信息
Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.6. doi: 10.1002/0471141755.ph0506s56.
Abstract
The subcutaneous air pouch is an in vivo model that can be used to study acute and chronic inflammation, the resolution of the inflammatory response, and the oxidative stress response. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this unit has been extensively used to identify potential anti-inflammatory drugs.
摘要
皮下气囊是一种可用于研究急性和慢性炎症、炎症反应的消退以及氧化应激反应的体内模型。向大鼠或小鼠的气囊中注射刺激物会引发炎症反应，这种反应可通过产生的渗出液体积、细胞浸润以及炎症介质的释放来进行量化。本单元介绍的模型已被广泛用于鉴定潜在的抗炎药物。
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