炎症模型：角叉菜胶气囊肿
Models of inflammation: carrageenan air pouch.
作者信息
Duarte Djane B, Vasko Michael R, Fehrenbacher Jill C
机构信息
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.
出版信息
Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.6. doi: 10.1002/0471141755.ph0506s56.
Abstract
The subcutaneous air pouch is an in vivo model that can be used to study acute and chronic inflammation, the resolution of the inflammatory response, and the oxidative stress response. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this unit has been extensively used to identify potential anti-inflammatory drugs.
摘要
皮下气囊是一种可用于研究急性和慢性炎症、炎症反应的消退以及氧化应激反应的体内模型。向大鼠或小鼠的气囊中注射刺激物会引发炎症反应，这种反应可通过产生的渗出液体积、细胞浸润以及炎症介质的释放来进行量化。本单元介绍的模型已被广泛用于鉴定潜在的抗炎药物。
相似文献
1
Models of inflammation: carrageenan air pouch.
Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.6. doi: 10.1002/0471141755.ph0506s56.
2
Models of Inflammation: Carrageenan Air Pouch.
Curr Protoc Pharmacol. 2016 Mar 18;72:5.6.1-5.6.9. doi: 10.1002/0471141755.ph0506s72.
3
Models of Inflammation: Carrageenan Air Pouch.
Curr Protoc. 2021 Aug;1(8):e183. doi: 10.1002/cpz1.183.
4
A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse.
Int J Tissue React. 1991;13(4):171-85.
5
Models of inflammation: Carrageenan- or complete Freund's Adjuvant (CFA)-induced edema and hypersensitivity in the rat.
Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.4. doi: 10.1002/0471141755.ph0504s56.
6
An interaction between genetic factors and gender determines the magnitude of the inflammatory response in the mouse air pouch model of acute inflammation.
Inflammation. 2005 Feb;29(1):1-7. doi: 10.1007/s10753-006-8962-6.
7
Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats.
Biofactors. 2006;26(1):17-28. doi: 10.1002/biof.5520260103.
8
Protective effect of the intravenous anesthetic propofol against a local inflammation in the mouse carrageenan-induced air pouch model.
Immunopharmacol Immunotoxicol. 2021 Feb;43(1):100-104. doi: 10.1080/08923973.2020.1869256. Epub 2021 Jan 11.
9
Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation.
Arthritis Rheum. 2005 Aug;52(8):2567-75. doi: 10.1002/art.21208.
10
Anti-inflammatory effects of an ethanol extract of Angelica gigas in a Carrageenan-air pouch inflammation model.
Exp Anim. 2009 Jul;58(4):431-6. doi: 10.1538/expanim.58.431.
引用本文的文献
1
Targeting vascular adhesion protein-1 and myeloperoxidase with a dual inhibitor SNT-8370 in preclinical models of inflammatory disease.
Nat Commun. 2025 Apr 11;16(1):3430. doi: 10.1038/s41467-025-58454-6.
2
(Cucurbitaceae) Shows Strong Anti-Inflammatory Activity in Murine Models of Acute Inflammation.
Pharmaceutics. 2024 Oct 4;16(10):1298. doi: 10.3390/pharmaceutics16101298.
3
Utilization of a highly adaptable murine air pouch model for minimally invasive testing of the inflammatory potential of biomaterials.
Front Bioeng Biotechnol. 2024 Apr 26;12:1367366. doi: 10.3389/fbioe.2024.1367366. eCollection 2024.
4
Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate.
Am J Physiol Endocrinol Metab. 2024 Jul 1;327(1):E55-E68. doi: 10.1152/ajpendo.00359.2023. Epub 2024 May 8.
5
Analgesic and Anti-inflammatory Potential of the New Tetrahydropyran Derivative (2s,6s)-6-ethyl-tetrahydro-2h-pyran-2-yl) Methanol.
Antiinflamm Antiallergy Agents Med Chem. 2024;23(2):105-117. doi: 10.2174/0118715230282982240202052127.
6
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway.
J Exp Med. 2024 Mar 4;221(3). doi: 10.1084/jem.20230124. Epub 2024 Jan 10.
7
Anti-Inflammatory Activity of '-(3-(1H-indol-3-yl)benzylidene)-2-cyanoacetohydrazide Derivative via sGC-NO/Cytokine Pathway.
Pharmaceuticals (Basel). 2023 Oct 5;16(10):1415. doi: 10.3390/ph16101415.
8
Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of L. (Papaveraceae).
Evid Based Complement Alternat Med. 2022 Nov 22;2022:6154560. doi: 10.1155/2022/6154560. eCollection 2022.
9
Inflammation at Site of Insulin Infusion Diminishes Glycemic Control.
J Pharm Sci. 2022 Jul;111(7):1952-1961. doi: 10.1016/j.xphs.2021.12.025. Epub 2022 Jan 2.
10
Advancing continuous subcutaneous insulin infusion in vivo: New insights into tissue challenges.
J Biomed Mater Res A. 2021 Jul;109(7):1065-1079. doi: 10.1002/jbm.a.37097. Epub 2020 Sep 18.
本文引用的文献
1
Etanercept administration prevents the inflammatory response induced by carrageenan in the murine air pouch model.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1247-57. doi: 10.1007/s00210-015-1162-x. Epub 2015 Aug 9.
2
Methanolic Extract of Ficus carica Linn. Leaves Exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation.
Evid Based Complement Alternat Med. 2015;2015:760405. doi: 10.1155/2015/760405. Epub 2015 Apr 21.
3
Amitriptyline, clomipramine, and maprotiline attenuate the inflammatory response by inhibiting neutrophil migration and mast cell degranulation.
Braz J Psychiatry. 2013 Oct-Dec;35(4):387-92. doi: 10.1590/1516-4446-2012-0977. Epub 2013 Dec 23.
4
Natural honey: a new and potent anti-angiogenic agent in the air-pouch model of inflammation.
Drug Res (Stuttg). 2014 Oct;64(10):530-6. doi: 10.1055/s-0033-1363229. Epub 2013 Dec 19.
5
TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.
J Lipid Res. 2011 Jul;52(7):1307-18. doi: 10.1194/jlr.M008045. Epub 2011 Apr 26.
6
Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation.
Inflamm Res. 2011 May;60(5):483-91. doi: 10.1007/s00011-010-0295-0. Epub 2010 Dec 23.
7
Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation.
Arthritis Rheum. 2009 May;60(5):1362-71. doi: 10.1002/art.24448.
8
Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor.
Mediators Inflamm. 1997;6(1):32-8. doi: 10.1080/09629359791901.
9
Anesthesia.
Curr Protoc Immunol. 2001 May;Chapter 1:Unit 1.4. doi: 10.1002/0471142735.im0104s27.
10
Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch.
Transpl Immunol. 2008 Apr;19(1):25-9. doi: 10.1016/j.trim.2008.01.003. Epub 2008 Jan 24.
Zotero 插件