McAtee Jesse R, Martin Sara E S, Ahneman Derek T, Johnson Keywan A, Watson Donald A
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3663-7. doi: 10.1002/anie.201200060. Epub 2012 Mar 1.
A high-yielding protocol for the palladium-catalyzed silylation of terminal alkenes using silyl halides is reported. This method allows facile conversion of styrenes to -β-silyl styrenes using either TMSI or TMSCl/LiI. Terminal allyl silanes with good ratios are also readily accessed from α-olefins by this method. When combined with existing technology, this transformation provides a powerful strategy to selectively functionalize the vinyl or allylic position of terminal alkenes.
报道了一种使用卤代硅烷进行钯催化末端烯烃硅氢化反应的高产率方法。该方法可通过使用TMSI或TMSCl/LiI将苯乙烯轻松转化为β-硅基苯乙烯。通过该方法也能从α-烯烃轻松获得具有良好比例的末端烯丙基硅烷。当与现有技术结合时,这种转化为选择性官能团化末端烯烃的乙烯基或烯丙基位置提供了一种强大的策略。