[抗坏血酸盐、还原型辅酶Ⅱ和氯地孕酮对犬和豚鼠肾上腺体外脂质过氧化的影响]
[The effect of ascorbate, NADPH and chloditan on lipid peroxidation in the adrenal glands of dogs and guinea pigs in vitro].
作者信息
Chelnakova I S, Tron'ko N D, Mikosha A S
出版信息
Vopr Med Khim. 1990 Jul-Aug;36(4):32-4.
Lipid peroxidation was studied in dog and guinea pig adrenal cortex homogenates in vitro in presence of ascorbate, NADPH and I-(o-chlorophenyl)-I-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD, chloditane) the substance exhibiting the specific impairing effect on human and dog adrenal gland cortex. The higher rate of spontaneous lipid peroxidation was detected in adrenal gland homogenates of guinea pig. NADPH inhibited accumulation of hydroperoxides in dog adrenal gland homogenates, while ascorbate-Fe2(+)-activated lipid peroxidation. Chloditane at concentrations 15.6 and 156 microM decreased the rate of spontaneous lipid peroxidation in dog adrenal gland homogenates and increased--in guinea pig preparations. Chloditane decreased distinctly the rate of lipid peroxidation in guinea pig adrenal gland homogenates, which was stimulated by ascorbate.
在体外，于抗坏血酸、NADPH和1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷（邻，对'-滴滴滴，氯狄氏剂）存在的情况下，对犬和豚鼠肾上腺皮质匀浆中的脂质过氧化进行了研究。氯狄氏剂这种物质对人和犬的肾上腺皮质具有特定的损害作用。在豚鼠的肾上腺匀浆中检测到较高的自发脂质过氧化速率。NADPH抑制了犬肾上腺匀浆中氢过氧化物的积累，而抗坏血酸 - Fe2(+) 激活了脂质过氧化。浓度为15.6和156微摩尔的氯狄氏剂降低了犬肾上腺匀浆中的自发脂质过氧化速率，而在豚鼠制剂中则升高了该速率。氯狄氏剂显著降低了豚鼠肾上腺匀浆中由抗坏血酸刺激的脂质过氧化速率。
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