Chelnakova I S, Tron'ko N D, Mikosha A S
Biull Eksp Biol Med. 1989 Feb;107(2):171-4.
The effect of adrenocorticolytic drug chloditan (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane;) on the content and the rate of lipid peroxidation in dog and guinea pig adrenals was studied. In adrenals of dogs and guinea the amount of malondialdehyde (MDA) was increased. In vitro spontaneous lipid peroxidation was delayed in adrenal homogenate of DDD-treated dogs. Spontaneous lipid peroxidation in adrenal homogenate was not decreased by feeding DDD in the guinea pig. DDD consumption did not affect on lipid peroxidation promoted by ascorbic acid and ferrous iron. The accumulation of MDA in dog and guinea pig adrenal homogenates was inhibited by NADPH.
研究了肾上腺皮质溶解药物氯地孕酮（1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷）对犬和豚鼠肾上腺中脂质过氧化含量及速率的影响。犬和豚鼠肾上腺中丙二醛（MDA）的含量增加。在经滴滴涕处理的犬的肾上腺匀浆中，体外自发性脂质过氧化受到延迟。在豚鼠中，喂食滴滴涕并没有降低肾上腺匀浆中的自发性脂质过氧化。滴滴涕的摄入并不影响由抗坏血酸和亚铁促进的脂质过氧化。烟酰胺腺嘌呤二核苷酸磷酸（NADPH）抑制了犬和豚鼠肾上腺匀浆中MDA的积累。
Zotero 插件