[氯地孕酮对犬和豚鼠肾上腺脂质过氧化的影响]

[Chloditan-induced changes in lipid peroxidation in the adrenals of dogs and guinea pigs].

作者信息

Chelnakova I S, Tron'ko N D, Mikosha A S

出版信息

Biull Eksp Biol Med. 1989 Feb;107(2):171-4.

Abstract

The effect of adrenocorticolytic drug chloditan (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane;) on the content and the rate of lipid peroxidation in dog and guinea pig adrenals was studied. In adrenals of dogs and guinea the amount of malondialdehyde (MDA) was increased. In vitro spontaneous lipid peroxidation was delayed in adrenal homogenate of DDD-treated dogs. Spontaneous lipid peroxidation in adrenal homogenate was not decreased by feeding DDD in the guinea pig. DDD consumption did not affect on lipid peroxidation promoted by ascorbic acid and ferrous iron. The accumulation of MDA in dog and guinea pig adrenal homogenates was inhibited by NADPH.

摘要

研究了肾上腺皮质溶解药物氯地孕酮（1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷）对犬和豚鼠肾上腺中脂质过氧化含量及速率的影响。犬和豚鼠肾上腺中丙二醛（MDA）的含量增加。在经滴滴涕处理的犬的肾上腺匀浆中，体外自发性脂质过氧化受到延迟。在豚鼠中，喂食滴滴涕并没有降低肾上腺匀浆中的自发性脂质过氧化。滴滴涕的摄入并不影响由抗坏血酸和亚铁促进的脂质过氧化。烟酰胺腺嘌呤二核苷酸磷酸（NADPH）抑制了犬和豚鼠肾上腺匀浆中MDA的积累。

相似文献

1

[Chloditan-induced changes in lipid peroxidation in the adrenals of dogs and guinea pigs].[氯地孕酮对犬和豚鼠肾上腺脂质过氧化的影响]

Biull Eksp Biol Med. 1989 Feb;107(2):171-4.

2

[The effect of ascorbate, NADPH and chloditan on lipid peroxidation in the adrenal glands of dogs and guinea pigs in vitro].[抗坏血酸盐、还原型辅酶Ⅱ和氯地孕酮对犬和豚鼠肾上腺体外脂质过氧化的影响]

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[Effect of O,N'=dichlorodiphenyldichloroethane and pertan in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs].[O,N'-二氯二苯二氯乙烷和培坦对犬和豚鼠肾上腺中谷胱甘肽还原酶活性的体外作用]

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6

[Effect of chloditan on the changes of activity of glutathione transferase, glutathione reductase and glutathione content in the adrenal glands and liver in rats].[氯地孕酮对大鼠肾上腺和肝脏中谷胱甘肽转移酶、谷胱甘肽还原酶活性及谷胱甘肽含量变化的影响]

Fiziol Zh (1994). 1994 Jan-Feb;40(1):86-90.

7

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8

[Analysis of the effect of chloditan on glutathione-S-transferase in the adrenals and liver].[氯地孕酮对肾上腺和肝脏中谷胱甘肽-S-转移酶的影响分析]

Farmakol Toksikol. 1985 Nov-Dec;48(6):104-6.

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[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane].[线粒体和微粒体电子传递的变化受邻，对'-二氯二苯二氯乙烷的影响]

Ukr Biokhim Zh (1978). 1981 Nov-Dec;53(6):74-7.

10

Metabolism and covalent binding of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p,'-DDD). Correlation between adrenocorticolytic activity and metabolic activation by adrenocortical mitochondria.1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷（邻，对'-滴滴滴）的代谢与共价结合。肾上腺皮质线粒体的肾上腺皮质溶解活性与代谢活化之间的相关性。

Drug Metab Dispos. 1980 May-Jun;8(3):127-30.

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