Mikosha A S, Chelnakova I S
Farmakol Toksikol. 1989 Sep-Oct;52(5):51-4.
The contents and the rates of the formation of lipid peroxides in the liver homogenates were studied. Dogs and guinea pigs were fed with chloditan in doses of 50 and 150 mg/kg body weight, respectively, for 20 days. In the dogs chloditan caused atrophy of the adrenal glands. The drug accumulation in the adrenal glands of the guinea pigs did not produce damage of the glands. The feeding with chloditan failed to change the level of malondialdehyde in the livers of the dogs and decreased it in the livers of the guinea pigs. In vitro spontaneous and NADP N-dependent lipid peroxidation in the liver homogenates of the dogs treated with chloditan was slowed. The decrease of malondialdehyde content in the guinea pig liver and the slowing of lipid peroxidation rate in the dog liver homogenate can be explained by the change in the activity of the enzymes detoxicating xenobiotics and products of lipid peroxidation.
研究了肝脏匀浆中脂质过氧化物的含量及形成速率。分别以50毫克/千克和150毫克/千克体重的剂量给狗和豚鼠喂食氯地孕酮，持续20天。氯地孕酮导致狗的肾上腺萎缩。豚鼠肾上腺中药物的蓄积并未对腺体造成损害。喂食氯地孕酮未能改变狗肝脏中丙二醛的水平，却降低了豚鼠肝脏中丙二醛的水平。体外实验中，用氯地孕酮处理的狗肝脏匀浆中的自发和NADP N依赖性脂质过氧化作用减缓。豚鼠肝脏中丙二醛含量的降低以及狗肝脏匀浆中脂质过氧化速率的减缓可以通过解毒异生物质和脂质过氧化产物的酶活性变化来解释。
