The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Cell Stem Cell. 2012 Mar 2;10(3):233-4. doi: 10.1016/j.stem.2012.02.012.
Mesenchymal stem cells (MSCs) are multipotential in vitro, but their endogenous properties are poorly defined. In this issue of Cell Stem Cell, Park et al. (2012) report that an MSC-like, osteolineage-directed Mx1+ population generates new osteoblasts at sites of bone damage, suggesting its potential for skeletal repair and regeneration.
间充质干细胞(MSCs)在体外具有多能性,但它们的内源性特性尚未完全明确。在本期的《Cell Stem Cell》杂志上,Park 等人(2012)报告称,一种 MSC 样、成骨谱系定向的 Mx1+细胞群体可在骨损伤部位产生新的成骨细胞,这提示其在骨骼修复和再生方面的潜在应用。