Department of Urology, University of California, Irvine, Orange, California 92868, USA.
Urology. 2012 Mar;79(3):733-7. doi: 10.1016/j.urology.2011.10.062.
The flow characteristics, ureteral conformance, and histopathologic changes of a novel spiral cut flexible ureteral stent (Percuflex Helical, Boston Scientific, Boston, MA) were evaluated in vivo in an acute and chronic porcine model.
Flow characteristics and ureteral conformance of the novel stent were determined in 6 acute and 6 chronic swine models and compared with a control ureteral stent (Percuflex Plus, Boston Scientific). The flow characteristics were determined in vivo after ligating the renal vessels and via a nephrostomy tube delivering a standard rate of 0.9% saline at 35 cm H(2)O. Flows in the unobstructed ureter, normal stent, intraluminally obstructed stent, extraluminal obstructed stent, and both intraluminally and extraluminally obstructed conditions were determined. In the chronic animals, flow was determined at day 10, with the stent in place and immediately after stent removal. Conformance and hydronephrosis was assessed on pyelograms. Histopathologic changes were also evaluated in the chronic animals.
The acute and chronic flow characteristics in the novel stent were equivalent to the control stent. Size and weight of the kidney, degree of hydronephrosis, stent migration, and presence of urinary tract infection were also similar between the test and control stents. There were no differences seen in histopathologic grading or degree of encrustation in either stent. The novel stent appeared to conform better to the shape of the ureter in both acute and chronic animals.
The novel helical stent appears to drain as well as a standard stent and causes no increased degree of histopathologic changes in the ureter.
在急性和慢性猪模型中，评估新型螺旋切割柔性输尿管支架（波士顿科学公司的 Percuflex Helical）的流动特性、输尿管顺应性和组织病理学变化。
在 6 个急性和 6 个慢性猪模型中，确定新型支架的流动特性和输尿管顺应性，并与对照输尿管支架（波士顿科学公司的 Percuflex Plus）进行比较。在结扎肾脏血管后，通过肾造瘘管以 35cmH₂O 的标准速率输送 0.9%生理盐水，在体内确定流动特性。在未阻塞的输尿管、正常支架、腔内阻塞的支架、腔外阻塞的支架以及腔内和腔外都阻塞的情况下，确定流量。在慢性动物中，在第 10 天放置支架和支架取出后立即确定流动。在肾盂造影片上评估顺应性和肾盂积水。还在慢性动物中评估组织病理学变化。
新型支架的急性和慢性流动特性与对照支架相当。新型和对照支架的肾脏大小和重量、肾盂积水程度、支架迁移和尿路感染发生率也相似。两种支架的组织病理学分级或结石附着程度均无差异。新型支架在急性和慢性动物中似乎都更能适应输尿管的形状。
新型螺旋支架的引流效果与标准支架相当，并且不会在输尿管中引起增加的组织病理学变化。
