Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.
Cardiovasc Res. 2012 May 1;94(2):293-303. doi: 10.1093/cvr/cvs109. Epub 2012 Mar 2.
Adverse cardiac remodelling is a major cause of morbidity and mortality following acute myocardial infarction (MI). Mechanical and neurohumoral factors involved in structural and molecular post-infarction remodelling were important targets in research and treatment for years. More recently, therapeutic strategies that address myocardial regeneration and pathophysiological mechanisms of infarct wound healing appear to be useful novel tools to prevent progressive ventricular dilation, functional deterioration, life-threatening arrhythmia, and heart failure. This review provides an overview of future and emerging therapies for cardiac wound healing and remodelling after MI.
心肌梗死后发生的不良心脏重构是导致发病率和死亡率的主要原因。机械和神经体液因素在结构和分子水平的梗死后重构中起重要作用，多年来一直是研究和治疗的重要靶点。最近，针对心肌再生和梗死愈合病理生理机制的治疗策略似乎是预防心室进行性扩张、功能恶化、威胁生命的心律失常和心力衰竭的有用新工具。本文综述了心肌梗死后心脏伤口愈合和重构的未来和新兴治疗方法。
