University of Pennsylvania, 3340 Smith Walk, Philadelphia, PA 19103, United States.
Int J Biochem Cell Biol. 2012 May;44(5):728-32. doi: 10.1016/j.biocel.2012.02.003. Epub 2012 Feb 24.
New technologies and interest in cell mechanics are generating exciting new discoveries about how material properties and forces affect biological structure and function. Mechanical forces are transduced via a variety of mechanisms, recently beginning to be revealed, into signals capable of altering cell function and structure. Responses to physical stimuli occur at multiple levels, from changes in the structures of single proteins to global cascades capable of altering cell proliferation and differentiation. This review describes recent findings in which physical stimuli were shown to modulate transcription factor activity, including that of armadillo/β-catenin, serum response factor (SRF), yes-associated protein (YAP) and nuclear factor κB (NF-κB).
新技术和对细胞力学的兴趣正在产生令人兴奋的新发现，揭示物质特性和力如何影响生物结构和功能。机械力通过多种机制进行转导，最近开始被揭示为能够改变细胞功能和结构的信号。对物理刺激的反应发生在多个层次上，从单个蛋白质结构的变化到能够改变细胞增殖和分化的全局级联反应。本综述描述了最近的发现，即物理刺激能够调节转录因子活性，包括装甲蛋白/β-连环蛋白、血清反应因子（SRF）、Yes 相关蛋白（YAP）和核因子κB（NF-κB）。
