Stephen Josena K, Chen Kang Mei, Havard Shaleta, Harris Glynis, Worsham Maria J
Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, MI, USA.
Methods Mol Biol. 2012;863:187-206. doi: 10.1007/978-1-61779-612-8_11.
In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.
除了基因的获得和缺失改变外，启动子甲基化的表观遗传事件似乎进一步破坏了头颈部鳞状细胞癌（HNSCC）中不稳定的基因组组成。本章概述了良性头颈部乳头状瘤、原发性HNSCC肿瘤和HNSCC细胞系中频繁甲基化的肿瘤抑制基因，以及它们作为头颈部肿瘤发生过程中表观遗传标志物的相关性。
