Hombhanje F
Department of Basic Medical Sciences, Faculty of Medicine, University of Papua New Guinea, Boroko, NCD.
P N G Med J. 1990 Jun;33(2):107-10.
A number of clinically useful drugs such as isoniazid, sulphonamides, procainamide and dapsone are rapidly inactivated and eliminated metabolically by an acetyltransferase enzyme. The rate of elimination of these drugs is dependent upon the level of enzymatic activity, which is known to be genetically determined and exhibits ethnic and geographical variation. The study of acetylation polymorphism therefore is important especially in view of its effect on drug efficacy and toxicity. Limited information is available on the acetylation status of Papua New Guineans. Studies conducted so far have revealed an unusually high frequency of the rapid acetylator phenotype (greater than 90%) in certain populations. This study confirms the previous observations and reviews the world-wide distribution pattern of acetylation polymorphism.
许多临床上有用的药物，如异烟肼、磺胺类药物、普鲁卡因胺和氨苯砜，会被一种乙酰转移酶迅速代谢失活并消除。这些药物的消除速率取决于酶活性水平，已知该酶活性由基因决定，并存在种族和地域差异。因此，乙酰化多态性的研究尤为重要，特别是考虑到其对药物疗效和毒性的影响。关于巴布亚新几内亚人的乙酰化状态，可用信息有限。迄今为止进行的研究表明，某些人群中快速乙酰化者表型的频率异常高（超过90%）。本研究证实了先前的观察结果，并综述了乙酰化多态性的全球分布模式。
