铜（I）醋酸盐催化叠氮-炔烃环加成反应，高效制备 1-(吡啶-2-基）-1,2,3-三唑。
Copper(I) acetate-catalyzed azide-alkyne cycloaddition for highly efficient preparation of 1-(pyridin-2-yl)-1,2,3-triazoles.
机构信息
Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
出版信息
Org Biomol Chem. 2012 Apr 14;10(14):2847-54. doi: 10.1039/c2ob06942c. Epub 2012 Mar 2.
PMID:22388558
Abstract
A highly efficient copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) of 6-substituted tetrazolo[1,5-a]pyridines was developed for the preparation of 1-(pyridin-2-yl)-1,2,3-triazoles by simply using copper(I) acetate as a catalyst. The in situ formed HOAc played important dual roles and an activation of 2-azidopyridine-copper(I) complex was observed.
摘要
发展了一种高效的铜（I）催化叠氮-炔环加成（CuAAC）反应，用于制备 1-（2-吡啶基）-1,2,3-三唑，只需使用醋酸铜（I）作为催化剂。原位生成的 HOAc 发挥了重要的双重作用，并观察到 2-叠氮吡啶-铜（I）配合物的活化。
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