Sun Ranfeng, Wang Huangdong, Hu Jianfeng, Zhao Jiudong, Zhang Hao
School of Chemical & Chemical Engineering, Inner Mongolia University, Hohhot 010021, P. R. China.
Org Biomol Chem. 2014 Aug 21;12(31):5954-63. doi: 10.1039/c4ob01176g.
A series of phosphinimine ligands were designed and used in the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines and alkynes for the first time. By optimizing the reaction conditions, an efficient catalytic system (CuCl/2-PyCH2N[double bond, length as m-dash]P(t)Bu3) was developed to give 1-(pyridin-2-yl)-1,2,3-triazole derivatives in moderate to excellent yields (46-98%).
首次设计了一系列磷亚胺配体，并将其用于四氮唑并[1,5 - a]吡啶与炔烃的铜（I）催化叠氮 - 炔环加成（CuAAC）反应中。通过优化反应条件，开发了一种高效的催化体系（CuCl/2 - PyCH₂N = P(t)Bu₃），以中等至优异的产率（46 - 98%）得到1 - （吡啶 - 2 - 基） - 1,2,3 - 三唑衍生物。
