Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5976-8. doi: 10.1016/j.bmcl.2012.07.022. Epub 2012 Jul 20.
A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.
利用（1H-1,2,3-三氮唑-1-基）苯并[d]噻唑的铜催化叠氮-炔点击反应（CuAAC），从互变异构的苯并[4,5]噻唑并[3,2-d]四唑（1）和 2-叠氮苯并[d]噻唑（2）起始原料出发，合成了许多（1H-1,2,3-三氮唑-1-基）苯并[d]噻唑。此外，研究过程中的一个产物，三唑苯并[d]噻唑 22，在人神经母细胞瘤（SH-SY5Y）细胞中表现出显著的神经保护活性。
