Reis Erica G, Gremião Isabella D F, Kitada Amanda A B, Rocha Raphael F D B, Castro Verônica S P, Barros Mônica B L, Menezes Rodrigo C, Pereira Sandro A, Schubach Tânia M P
Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas Clinical Research Institute/Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
J Feline Med Surg. 2012 Jun;14(6):399-404. doi: 10.1177/1098612X12441317. Epub 2012 Mar 2.
Sporotrichosis is a mycosis caused by Sporothrix schenckii. The most affected animal is the cat; it has played an important role in the zoonotic transmission of this disease, especially in Rio de Janeiro, Brazil, since 1998. In order to evaluate the treatment of feline sporotrichosis with potassium iodide, an observational cohort was conducted in 48 cats with sporotrichosis at Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz. All cats received potassium iodide capsules, 2.5 mg/kg to 20 mg/kg q24h. The cure rate was 47.9%, treatment failure was 37.5%, treatment abandonment was 10.4% and death was 4.2%. Clinical adverse effects were observed in 52.1% of the cases. Thirteen cats had a mild increase in hepatic transaminase levels during the treatment, six of them presented clinical signs suggestive of hepatotoxicity. Compared to previous studies with itraconazole and iodide in saturated solution, potassium iodide capsules are an alternative for feline sporotrichosis treatment.
孢子丝菌病是由申克孢子丝菌引起的一种真菌病。受影响最严重的动物是猫；自1998年以来，它在这种疾病的人畜共患病传播中发挥了重要作用，尤其是在巴西里约热内卢。为了评估碘化钾对猫孢子丝菌病的治疗效果，在巴西奥斯瓦尔多·克鲁兹基金会临床研究机构伊瓦尔多·查加斯临床研究所对48只患有孢子丝菌病的猫进行了一项观察性队列研究。所有的猫都接受碘化钾胶囊治疗，剂量为2.5毫克/千克至20毫克/千克，每24小时一次。治愈率为47.9%，治疗失败率为37.5%，治疗中断率为10.4%，死亡率为4.2%。52.1%的病例观察到临床不良反应。13只猫在治疗期间肝转氨酶水平轻度升高，其中6只出现提示肝毒性的临床症状。与之前使用伊曲康唑和饱和溶液碘化物的研究相比，碘化钾胶囊是治疗猫孢子丝菌病的一种替代方法。
