Yale University School of Medicine, Yale University, New Haven, CT, USA.
Cell Mol Life Sci. 2012 Aug;69(16):2635-56. doi: 10.1007/s00018-012-0942-4. Epub 2012 Mar 3.
Heart disease is one of the leading causes of death worldwide and the number of patients with the disease is likely to grow with the continual decline in health for most of the developed world. Heart transplantation is one of the only treatment options for heart failure due to an acute myocardial infarction, but limited donor supply and organ rejection limit its widespread use. Cellular cardiomyoplasty, or cellular implantation, combined with various tissue-engineering methods aims to regenerate functional heart tissue. This review highlights the numerous cell sources that have been used to regenerate the heart as well as cover the wide range of tissue-engineering strategies that have been devised to optimize the delivery of these cells. It will probably be a long time before an effective regenerative therapy can make a serious impact at the bedside.
心脏病是全球主要死因之一，随着大多数发达国家健康状况持续下降，心脏病患者数量可能会增加。心脏移植是因急性心肌梗死导致心力衰竭的唯一治疗选择之一，但供体有限和器官排斥限制了其广泛应用。细胞心肌成形术或细胞植入与各种组织工程方法相结合，旨在再生功能性心脏组织。本综述重点介绍了已用于再生心脏的多种细胞来源，并涵盖了为优化这些细胞的输送而设计的广泛的组织工程策略。在有效的再生疗法能够在床边产生重大影响之前，可能还需要很长时间。
