National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China.
Nat Struct Mol Biol. 2012 Mar 4;19(4):424-9. doi: 10.1038/nsmb.2255.
Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can cause severe central nervous system disease and death. No vaccine or antiviral therapy is available. High-resolution structural analysis of the mature virus and natural empty particles shows that the mature virus is structurally similar to other enteroviruses. In contrast, the empty particles are markedly expanded and resemble elusive enterovirus-uncoating intermediates not previously characterized in atomic detail. Hydrophobic pockets in the EV71 capsid are collapsed in this expanded particle, providing a detailed explanation of the mechanism for receptor-binding triggered virus uncoating. These structures provide a model for enterovirus uncoating in which the VP1 GH loop acts as an adaptor-sensor for cellular receptor attachment, converting heterologous inputs to a generic uncoating mechanism, highlighting new opportunities for therapeutic intervention.
肠道病毒 71 型（EV71）是导致儿童手足口病的主要病原体，可引起严重的中枢神经系统疾病和死亡。目前尚无疫苗或抗病毒疗法。成熟病毒和天然空病毒颗粒的高分辨率结构分析表明，成熟病毒的结构与其他肠道病毒相似。相比之下，空病毒颗粒明显扩张，类似于以前未在原子水平详细描述的难以捉摸的肠道病毒脱壳中间体。EV71 衣壳中的疏水口袋在这个扩张的颗粒中塌陷，为受体结合触发病毒脱壳的机制提供了详细的解释。这些结构为肠道病毒脱壳提供了一个模型，其中 VP1 GH 环作为细胞受体附着的适配子-传感器，将异源输入转化为通用的脱壳机制，突出了治疗干预的新机会。
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