c-Kit 原癌基因在子宫内膜增生症和子宫内膜癌中的表达。
c-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer.
机构信息
Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey.
出版信息
Arch Gynecol Obstet. 2012 Jul;286(1):197-200. doi: 10.1007/s00404-012-2276-8. Epub 2012 Mar 6.
PURPOSE
To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer.
METHODS
Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry.
RESULTS
c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia.
CONCLUSIONS
Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion.
目的
评估 c-kit（CD117）在子宫内膜增生和子宫内膜癌中的表达。
方法
采用免疫组织化学法检测 10 例正常子宫内膜、18 例单纯性子宫内膜增生、16 例复杂性子宫内膜增生（10 例伴不典型增生和 6 例不伴不典型增生）和 6 例子宫内膜癌中 c-kit 的表达。
结果
c-Kit 表达随着病变进展为子宫内膜癌而降低。正常子宫内膜的免疫染色多为局灶性和弱阳性，而单纯性和复杂性子宫内膜增生则多为弥漫性和强阳性。
结论
单纯性和复杂性增生性子宫内膜组织表达弥漫性细胞质 c-kit 染色，随着病变的进展，其表达减少。
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