Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, International Center for the Assessment of Nutritional Status, Università degli Studi di Milano, Via G. Celoria, 2, 20133, Milan, Italy.
Plant Foods Hum Nutr. 2012 Mar;67(1):100-4. doi: 10.1007/s11130-012-0282-4.
We hypothesized that fruit ingestion provides measurable amounts of salicylic acid (SA) and produces different metabolic and inflammatory responses compared to mere fruit sugars. In a randomized-crossover study, 26 healthy subjects received a peach shake meal (PSM) (SA: 0,06 ± 0,001 mg/100 g) and a mixed sugar meal (MSM), consisting in an aqueous solution with the same sugars found in the peach shake. In order to control for the SA contribution from meals in the previous day, 16 subjects (Group 1) abstained from fruits and vegetables consumption the evening before trials, and 10 subjects (Group 2) maintained their usual diet. Circulating SA, glucose, insulin, free fatty acids, and interleukin-6 were determined. Basal SA was lower in Group 1 than in Group 2 (0.09 ± 0.02 vs. 0.30 ± 0.03 μmol/l, p < 0.001), peaked at 90 min in both groups (0.18 ± 0.01 vs. 0.38 ± 0.02 μmol/l, p < 0.01) and remained above baseline (p < 0.05) up to 3 h. Glycemia increased less after PSM at 15 min (p < 0.01) with a lower average glucose excursion (p < 0.05). Insulin peaked at 45 min with both meals but decreased less rapidly with PSM. Free fatty acids decreased more (p < 0.01), and interleukin-6 increased less (p < 0.05) with PSM. Dietary fruit intake increases the concentration of SA in vivo, and provides non-nutrients capable to modulate the inflammatory and metabolic responses to carbohydrates.
我们假设，与单纯的水果糖相比，摄入水果可提供可衡量的水杨酸（SA）并产生不同的代谢和炎症反应。在一项随机交叉研究中，26 名健康受试者分别接受了桃汁奶昔餐（PSM）（SA：0.06±0.001mg/100g）和混合糖餐（MSM），这两种餐均由与桃汁奶昔中相同的糖组成的水溶液。为了控制前一天的餐食对 SA 的贡献，16 名受试者（第 1 组）在试验前的晚上避免食用水果和蔬菜，而 10 名受试者（第 2 组）保持他们的日常饮食。测定循环 SA、葡萄糖、胰岛素、游离脂肪酸和白细胞介素-6。第 1 组的基础 SA 低于第 2 组（0.09±0.02 对 0.30±0.03μmol/l，p<0.001），两组均在 90 分钟时达到峰值（0.18±0.01 对 0.38±0.02μmol/l，p<0.01），并在 3 小时内保持在基线以上（p<0.05）。PSM 在 15 分钟后使血糖升高幅度更小（p<0.01），平均血糖波动幅度更小（p<0.05）。胰岛素在两餐时均在 45 分钟时达到峰值，但 PSM 后下降速度较慢。PSM 时游离脂肪酸下降幅度更大（p<0.01），白细胞介素-6 升高幅度更小（p<0.05）。饮食中摄入水果会增加体内 SA 的浓度，并提供非营养物质，能够调节碳水化合物的炎症和代谢反应。
