Paterson John R, Baxter Gwendoline, Dreyer Jacob S, Halket John M, Flynn Robert, Lawrence James R
Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG1 4AP, United Kingdom.
J Agric Food Chem. 2008 Dec 24;56(24):11648-52. doi: 10.1021/jf800974z.
Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.
水杨酸（SA）是植物防御机制的核心成分，也是阿司匹林的主要代谢产物，在人体内自然存在，素食者体内较高水平的SA及其尿液代谢产物水杨尿酸（SU）与低剂量阿司匹林治疗患者的水平重叠。SA广泛分布于动物血液中。即使是接受全直肠结肠切除术的患者，为进行大型结直肠手术而禁食也不会导致血浆中SA消失。六名志愿者摄入（13）C（6）苯甲酸后，在8至16小时内，尿水杨尿酸的中位标记率为33.9%。因此，苯甲酸（及其盐类）对循环SA周转的总体贡献需要进一步评估。然而，SA似乎至少部分是一种内源性化合物，这应该促使人们重新评估其在人类（和动物）病理生理学中的作用。
