Zhang Xiang-Sheng, Dong Hong-Yan, Zhang Lei-Lei, Desouki Mohamed Mokhtar, Zhao Chengquan
1. Department of Pathology , Binzhou Medical College, Binzhou 256603, China;
J Cancer. 2012;3:100-6. doi: 10.7150/jca.3929. Epub 2012 Feb 23.
This is a series of three cases diagnosed with xanthogranulomatous inflammation of the female genital with emphasis on the etiology, clinical-pathologic features and biological behavior. Clinical, pathologic, radiologic and follow up data are reported.
The three cases of Xanthogranulomatous inflammation of the female genital tract are the followings: 1) one case affecting the endometrium, 2) one case affecting the fallopian tube, and 3) one case confined to the ovary. The patient's age was 37, 22 and 62 year-old, respectively. Histologic examination revealed extensive infiltration of foamy histiocytes admixed with variable amount of inflammatory cells. The later include plasma cells, lymphocytes, and occasional multinucleated giant cells. Immunohistochemistry showed positive staining for CD68, a histiocytic marker, in foamy histiocytes, CD3, a T cell marker, and CD20, a B cell marker, in the background lymphocytes. The plasma cells were polyclonal with expression of both κ and λ light chains.
Xanthogranulomatous inflammation of the female genital tract is an unusual lesion, and clinically forms mass- like lesion in the pelvic cavity that invades the surrounding tissues, which may mimic the tumor clinically and by imaging.
本文报道3例女性生殖器黄色肉芽肿性炎症病例，重点阐述其病因、临床病理特征及生物学行为。报告了临床、病理、影像学及随访资料。
3例女性生殖道黄色肉芽肿性炎症病例如下：1）1例累及子宫内膜；2）1例累及输卵管；3）1例局限于卵巢。患者年龄分别为37岁、22岁和62岁。组织学检查显示大量泡沫状组织细胞浸润，并伴有数量不等的炎症细胞，后者包括浆细胞、淋巴细胞及偶尔出现的多核巨细胞。免疫组化显示，泡沫状组织细胞中组织细胞标志物CD68呈阳性染色，背景淋巴细胞中T细胞标志物CD3及B细胞标志物CD20呈阳性染色。浆细胞为多克隆性，κ和λ轻链均有表达。
女性生殖道黄色肉芽肿性炎症是一种罕见病变，临床上在盆腔形成肿块样病变并侵犯周围组织，在临床及影像学上可能类似肿瘤。
