Xuan W Y, Zhao Y, Li A Y, Xie P S, Liu X
Guangxi College of Traditional Chinese Medicine, Nanning.
Yao Xue Xue Bao. 1990;25(3):220-2.
Artensunate transdermal preparation at 5, 10, or 15 mg/kg, bid, for 3 days applied locally on the shaved skin of the back of monkeys showed reliable therapeutic effects on Plasmodium cynomolgi, but recrudescence of the parasites was not controlled. If some azone was added in the artesunate transdermal preparation at the dosage of 5 mg/kg, bid, for 3 days, the parasitemia of Plasmodium cynomolgi could be cleared and recrudescence prevented, thus, the antimalarial effects was enhanced.
将青蒿琥酯透皮制剂以5、10或15mg/kg的剂量，每日两次，连续3天局部应用于猴背部剃毛的皮肤上，对食蟹猴疟原虫显示出可靠的治疗效果，但未能控制寄生虫的复发。如果在青蒿琥酯透皮制剂中加入一些氮酮，以5mg/kg的剂量，每日两次，连续3天，则食蟹猴疟原虫的虫血症可以清除并防止复发，从而增强抗疟效果。
