Novákné Pékli M
Semmelweis Orvostudományi Egyetem Gyógyszerészi Kémiai Intézet, Budapest.
Acta Pharm Hung. 1990 Jul;60(4):162-4.
A bromatometric method was elaborated for the quantitative determination of oxprenolol. 15 to 150 mg of oxprenolol dissolved in 10 cm3 of water is brominated by adding 20.00-40.00 cm3 of 0.02 or 0.1 N potassium bromate solution followed by 0.5-3 g of potassium bromide and 1-10 cm3 of 10% w/w hydrochloric acid. After a reaction time of 15 min. 2-10 cm3 of 10% w/w potassium iodide solution is added followed by 20-40 cm3 of chloroform. The liberated iodine is titrated with standard 0.1 N or 0.01 N sodium thiosulphate solution. A blank titration is also performed and the oxprenolol content is calculated from the difference of the two titrations. Under these conditions one oxprenolol molecule reacts with six bromine atoms. The relative standard deviation is 1.31%.
建立了一种用溴量法测定氧烯洛尔的定量方法。将15至150毫克氧烯洛尔溶于10立方厘米水中，加入20.00 - 40.00立方厘米0.02或0.1N溴酸钾溶液，接着加入0.5 - 3克溴化钾和1 - 10立方厘米10%（重量/重量）盐酸进行溴化反应。反应15分钟后，加入2 - 10立方厘米10%（重量/重量）碘化钾溶液，然后加入20 - 40立方厘米氯仿。用标准0.1N或0.01N硫代硫酸钠溶液滴定释放出的碘。同时进行空白滴定，并根据两次滴定的差值计算氧烯洛尔的含量。在这些条件下，一个氧烯洛尔分子与六个溴原子反应。相对标准偏差为1.31%。
