Centre for Evaluation of Vaccination, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Vaccine. 2011 Mar 3;29(11):2222-6. doi: 10.1016/j.vaccine.2010.06.004. Epub 2010 Jun 15.
Kinetics of maternal rubella and varicella antibodies in 213 mother-infant pairs are described in a longitudinal study in Belgium. Blood samples are taken at 7 time points (week 36 of pregnancy, birth (cord), 1, 3, 6, 9, and 12 months), and analyzed for anti-rubella IgG and anti-varicella IgG by enzyme linked immunosorbent assay (ELISA). A generalized exponential model is used to analyse maternal antibody decay in infants. Model based, the mean duration of passive immunity is 2.1 months for rubella and 2.4 months for varicella. Infants are susceptible at young age for rubella, a disease with high vaccination coverage, as well as for varicella, an endemic disease in Western Europe.
在比利时进行的一项纵向研究中，描述了 213 对母婴对的母体风疹和水痘抗体的动力学。在 7 个时间点（妊娠第 36 周、出生（脐带）、1、3、6、9 和 12 个月）采集血样，并通过酶联免疫吸附试验（ELISA）分析抗风疹 IgG 和抗水痘 IgG。使用广义指数模型分析婴儿体内母体抗体的衰减。基于模型，风疹的被动免疫平均持续时间为 2.1 个月，水痘为 2.4 个月。风疹是一种高疫苗接种覆盖率的疾病，水痘是西欧的一种地方病，因此婴儿在年幼时易受感染。
