成骨细胞产生 FGF23。
FGF23 production by osteocytes.
机构信息
School of Dentistry, University of Missouri, 650 East 25th Street, Kansas City, MO, 64108-2784, USA.
出版信息
Pediatr Nephrol. 2013 Apr;28(4):563-8. doi: 10.1007/s00467-012-2309-3. Epub 2012 Sep 16.
Abstract
Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease. Associations between serum FGF23 level and vascular dysfunction, vascular calcification, and increased risk of cardiovascular disease have also been observed. In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level.
摘要
成纤维细胞生长因子 23（FGF23）是一种已知的磷酸盐稳态调节剂，由存在于骨中的细胞（即骨细胞）产生，以靶向远处的器官，即肾脏。最近在慢性肾脏病患者和动物模型中发现了全身性和骨细胞中升高的 FGF23 水平。还观察到血清 FGF23 水平与血管功能障碍、血管钙化和心血管疾病风险增加之间存在关联。在这篇综述中，我们讨论了骨细胞中的 FGF23 表达以及在骨细胞水平上调节这种蛋白质表达和功能的潜在方法。
相似文献
1
FGF23 production by osteocytes.成骨细胞产生 FGF23。
Pediatr Nephrol. 2013 Apr;28(4):563-8. doi: 10.1007/s00467-012-2309-3. Epub 2012 Sep 16.
2
Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD.在 CKD 患者血磷升高期间，升高的 FGF23 可预防心脏-肾脏不良后果。
JCI Insight. 2019 Feb 21;4(4). doi: 10.1172/jci.insight.123817.
3
Bone mineralization is regulated by signaling cross talk between molecular factors of local and systemic origin: the role of fibroblast growth factor 23.骨矿化是由局部和全身来源的分子因子的信号串扰调节的：成纤维细胞生长因子 23 的作用。
Biofactors. 2014 Nov-Dec;40(6):555-68. doi: 10.1002/biof.1186. Epub 2014 Oct 29.
4
Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease.成纤维细胞生长因子23的产生与裂解的耦合：缺铁、佝偻病和肾脏疾病。
Curr Opin Nephrol Hypertens. 2014 Jul;23(4):411-9. doi: 10.1097/01.mnh.0000447020.74593.6f.
5
Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo.成骨细胞中甲状旁腺激素受体信号转导增加了体内外成纤维细胞生长因子 23 的表达。
Bone. 2011 Oct;49(4):636-43. doi: 10.1016/j.bone.2011.06.025. Epub 2011 Jun 25.
6
[FGF23 and osteonetwork].[成纤维细胞生长因子23与骨网络]
Clin Calcium. 2016 Aug;26(8):1143-7.
7
High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.高钙、磷酸盐和骨化三醇补充会导致钙化血管中的骨细胞样表型和尿毒症大鼠的骨矿物质化缺陷。
J Bone Miner Metab. 2019 Mar;37(2):212-223. doi: 10.1007/s00774-018-0919-y. Epub 2018 Mar 30.
8
Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway.骨-肾矿物质与能量代谢的调节：PHEX、FGF23、DMP1、MEPE ASARM信号通路
Crit Rev Eukaryot Gene Expr. 2012;22(1):61-86. doi: 10.1615/critreveukargeneexpr.v22.i1.50.
9
Vitamin D sterols increase FGF23 expression by stimulating osteoblast and osteocyte maturation in CKD bone.维生素 D 甾醇通过刺激 CKD 骨骼中的成骨细胞和骨细胞成熟来增加 FGF23 的表达。
Bone. 2019 Oct;127:626-634. doi: 10.1016/j.bone.2019.07.026. Epub 2019 Aug 1.
10
Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis.证据表明 FGF23 参与了一个骨-肾轴的调节，该轴调节骨矿物质化和全身磷酸盐及维生素 D 稳态。
Adv Exp Med Biol. 2012;728:65-83. doi: 10.1007/978-1-4614-0887-1_4.
引用本文的文献
1
Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank.老年人群跟骨骨密度与新发痴呆症的关联：一项基于英国生物银行的人群研究
Aging Clin Exp Res. 2025 Jul 16;37(1):217. doi: 10.1007/s40520-025-03100-w.
2
New and Emerging Biomarkers in Chronic Kidney Disease.慢性肾脏病中的新型和新兴生物标志物
Biomedicines. 2025 Jun 10;13(6):1423. doi: 10.3390/biomedicines13061423.
3
Bone mechanical loading reduces heart rate and increases heart rate variability in mice.骨骼机械负荷可降低小鼠心率并增加其心率变异性。
Bone Rep. 2025 Apr 16;25:101844. doi: 10.1016/j.bonr.2025.101844. eCollection 2025 Jun.
4
MLO-Y4 fluid flow shear stress conditioned media enhances cardiac contractility and intracellular Ca.MLO-Y4流体流动剪切应力条件培养基可增强心脏收缩力和细胞内钙离子浓度。
Am J Physiol Regul Integr Comp Physiol. 2025 May 1;328(5):R591-R600. doi: 10.1152/ajpregu.00287.2024. Epub 2025 Mar 26.
5
The Crosstalk Between Cartilage and Bone in Skeletal Growth.骨骼生长过程中软骨与骨之间的相互作用
Biomedicines. 2024 Nov 21;12(12):2662. doi: 10.3390/biomedicines12122662.
6
Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes.β-丙氨酸的两种对映异构体 BAICA 通过激活破骨细胞中不同的信号通路，通过 MRGPRD 受体调节 Fgf23。
Cell Rep. 2024 Jul 23;43(7):114397. doi: 10.1016/j.celrep.2024.114397. Epub 2024 Jun 25.
7
Gα11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia.Gα11 缺失在家族性低钙血症性高钙血症的小鼠模型中增加成纤维细胞生长因子 23 水平。
JCI Insight. 2024 Mar 26;9(9):e178993. doi: 10.1172/jci.insight.178993.
8
Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date.心脏和肾脏纤维化：心血管连续体中的沉默杀手——最新进展
J Cardiovasc Dev Dis. 2024 Feb 16;11(2):62. doi: 10.3390/jcdd11020062.
9
Spectrum of PHEX Mutations and FGF23 Profiles in a Taiwanese Cohort With X-Linked Hypophosphatemia Including 102 Patients.台湾地区 X 连锁低磷血症患者 PHEX 基因突变谱及 FGF23 特征：包含 102 例患者的研究
In Vivo. 2024 Jan-Feb;38(1):341-350. doi: 10.21873/invivo.13444.
10
Sclerostin, Osteocytes, and Wnt Signaling in Pediatric Renal Osteodystrophy.骨硬化蛋白、骨细胞和成骨细胞分化因子在儿童肾性骨营养不良中的作用
Nutrients. 2023 Sep 25;15(19):4127. doi: 10.3390/nu15194127.
本文引用的文献
1
Mechanism of FGF23 processing in fibrous dysplasia.纤维性骨发育不良中 FGF23 的加工机制。
J Bone Miner Res. 2012 May;27(5):1132-41. doi: 10.1002/jbmr.1546.
2
FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages.成纤维细胞生长因子 23 与血管钙化相关，但与不同 CKD 分期患者的骨密度无关。
Osteoporos Int. 2012 Jul;23(7):2017-25. doi: 10.1007/s00198-011-1838-0. Epub 2011 Nov 23.
3
Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study.成纤维细胞生长因子 23、心血管疾病危险因素与健康专业人员随访研究中的磷摄入量。
Clin J Am Soc Nephrol. 2011 Dec;6(12):2871-8. doi: 10.2215/CJN.02740311. Epub 2011 Oct 27.
4
Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease.慢性肾脏病小鼠模型中 FGF23 变化及矿物质代谢异常的纵向评估。
J Bone Miner Res. 2012 Jan;27(1):38-46. doi: 10.1002/jbmr.516.
5
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.铁缺乏导致成纤维细胞生长因子 23（Fgf23）敲入小鼠中常染色体显性低磷血症性佝偻病（ADHR）表型。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1146-55. doi: 10.1073/pnas.1110905108. Epub 2011 Oct 17.
6
FGF23 induces left ventricular hypertrophy.成纤维细胞生长因子 23 可诱导左心室肥厚。
J Clin Invest. 2011 Nov;121(11):4393-408. doi: 10.1172/JCI46122. Epub 2011 Oct 10.
7
Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women.血清成纤维细胞生长因子 23 与老年社区女性心血管疾病的关系。
Eur J Endocrinol. 2011 Nov;165(5):797-803. doi: 10.1530/EJE-11-0577. Epub 2011 Aug 26.
8
Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease.慢性肾脏病中肾素-血管紧张素-醛固酮系统与维生素 D-FGF-23-klotho 的相互作用。
J Am Soc Nephrol. 2011 Sep;22(9):1603-9. doi: 10.1681/ASN.2010121251. Epub 2011 Aug 18.
9
Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo.IDG-SW3 细胞系在体外复制成骨细胞向晚期成骨细胞分化，并在体内加速骨形成。
J Bone Miner Res. 2011 Nov;26(11):2634-46. doi: 10.1002/jbmr.465.
10
Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.成纤维细胞生长因子 23 通过成纤维细胞生长因子受体 3 和 4 调节血清 1,25(OH)2 维生素 D3 水平。
Am J Physiol Renal Physiol. 2011 Aug;301(2):F371-7. doi: 10.1152/ajprenal.00740.2010. Epub 2011 May 11.
Zotero 插件