唐氏综合征：其真的以免疫衰老提前为特征吗？
Down syndrome: is it really characterized by precocious immunosenescence?
机构信息
Department of Pediatrics, Jeroen Bosch Hospital,'s-Hertogenbosch, the Netherlands.
出版信息
Aging Dis. 2011 Dec;2(6):538-45. Epub 2011 Dec 2.
Abstract
The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in the adaptive immune system of Down syndrome in comparison to normal and precocious (Progeria syndromes) aging. Clinical signs and immunological changes are reviewed. We challenge the hypothesis that the immunological abnormalities in Down syndrome should be interpreted as precocious immunosenescence.
摘要
免疫系统随年龄增长而衰退，导致感染易感性增加，自身免疫现象和肿瘤的发生率和进展率更高。唐氏综合征提前表现出通常与衰老相关的临床症状。与正常和早衰（早衰综合征）衰老相比，本综述简要概述了唐氏综合征适应性免疫系统的异常。综述了临床症状和免疫学变化。我们对唐氏综合征的免疫异常应被解释为过早的免疫衰老这一假说提出了质疑。
相似文献
1
Down syndrome: is it really characterized by precocious immunosenescence?唐氏综合征：其真的以免疫衰老提前为特征吗？
Aging Dis. 2011 Dec;2(6):538-45. Epub 2011 Dec 2.
2
Down syndrome, accelerated aging and immunosenescence.唐氏综合征、加速衰老与免疫衰老。
Semin Immunopathol. 2020 Oct;42(5):635-645. doi: 10.1007/s00281-020-00804-1. Epub 2020 Jul 23.
3
Helminth infections and immunosenescence: The friend of my enemy.寄生虫感染与免疫衰老：敌人的朋友。
Exp Gerontol. 2020 May;133:110852. doi: 10.1016/j.exger.2020.110852. Epub 2020 Jan 30.
4
The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE).衰老和免疫衰老（ISC）对多发性硬化症（MS）和动物对应实验性自身免疫性脑脊髓炎（EAE）中适应性免疫的影响和作用。
Ageing Res Rev. 2018 Jan;41:64-81. doi: 10.1016/j.arr.2017.10.005. Epub 2017 Oct 31.
5
Precocious aging and dementia in patients with Down's syndrome.唐氏综合征患者的早衰与痴呆
Biol Psychiatry. 1978 Oct;13(5):619-27.
6
Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?急性和慢性运动对老年人免疫参数的影响：身体活动能对抗衰老的影响吗？
Front Immunol. 2018 Oct 10;9:2187. doi: 10.3389/fimmu.2018.02187. eCollection 2018.
7
Immunosenescence and lymphomagenesis.免疫衰老与淋巴瘤发生
Immun Ageing. 2018 Sep 21;15:22. doi: 10.1186/s12979-018-0130-y. eCollection 2018.
8
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?免疫衰老与衰老过程中的炎症：与年龄相关的疾病还是长寿？
Ageing Res Rev. 2021 Nov;71:101422. doi: 10.1016/j.arr.2021.101422. Epub 2021 Aug 13.
9
When wrinkles appear on the immune system can it be reversed?当免疫系统出现皱纹时，它能被逆转吗？
Eur Cytokine Netw. 2020 Mar 1;31(1):1-17. doi: 10.1684/ecn.2020.0441.
10
Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.衰老细胞模型中水痘带状疱疹病毒感染（带状疱疹）期间免疫衰老作用的见解。
Oncotarget. 2015 Nov 3;6(34):35324-43. doi: 10.18632/oncotarget.6117.
引用本文的文献
1
IgG1 glycosylation highlights premature aging in Down syndrome.IgG1 糖基化突出了唐氏综合征的早衰现象。
Aging Cell. 2024 Jul;23(7):e14167. doi: 10.1111/acel.14167. Epub 2024 Apr 15.
2
Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.深度免疫表型分析揭示衰老、唐氏综合征和自身免疫之间的相似性。
Sci Transl Med. 2022 Jan 12;14(627):eabi4888. doi: 10.1126/scitranslmed.abi4888.
3
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.免疫失调与唐氏综合征成人呼吸道感染后并发症和死亡率增加的关系。
Front Immunol. 2021 Jun 25;12:621440. doi: 10.3389/fimmu.2021.621440. eCollection 2021.
4
Down syndrome, accelerated aging and immunosenescence.唐氏综合征、加速衰老与免疫衰老。
Semin Immunopathol. 2020 Oct;42(5):635-645. doi: 10.1007/s00281-020-00804-1. Epub 2020 Jul 23.
5
Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.靶向唐氏综合征和衰老中的线粒体网络架构。
Int J Mol Sci. 2020 Apr 29;21(9):3134. doi: 10.3390/ijms21093134.
6
A Prevalent CXCR3 Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome.循环滤泡辅助性 T 细胞中 CXCR3 表型普遍存在，表明唐氏综合征患儿存在体液失调。
J Clin Immunol. 2020 Apr;40(3):447-455. doi: 10.1007/s10875-020-00755-0. Epub 2020 Jan 28.
7
Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells.并置（异体共生）不能完全逆转衰老引起的小鼠红细胞代谢变化和氧化应激。
Nutrients. 2019 Jun 14;11(6):1337. doi: 10.3390/nu11061337.
8
Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development.DiGeorge 综合征和唐氏综合征患者的胸腺上皮异常导致 T 细胞发育失调。
Front Immunol. 2019 Mar 15;10:447. doi: 10.3389/fimmu.2019.00447. eCollection 2019.
9
Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies.唐氏综合征中的加速生物认知衰老：最新进展与可能的减速策略。
Aging Cell. 2019 Jun;18(3):e12903. doi: 10.1111/acel.12903. Epub 2019 Feb 15.
10
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.衰老与年龄相关疾病的连续体：共同机制但速率不同。
Front Med (Lausanne). 2018 Mar 12;5:61. doi: 10.3389/fmed.2018.00061. eCollection 2018.
本文引用的文献
1
Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency?唐氏综合征的免疫评估和疫苗反应：免疫缺陷的证据？
Vaccine. 2011 Jul 12;29(31):5040-6. doi: 10.1016/j.vaccine.2011.04.060. Epub 2011 May 17.
2
Inflammatory and Immunological parameters in adults with Down syndrome.唐氏综合征成人的炎症和免疫参数。
Immun Ageing. 2011 Apr 16;8(1):4. doi: 10.1186/1742-4933-8-4.
3
T lymphocytes apoptosis and mitochondrial membrane potential in Down's syndrome.唐氏综合征中的T淋巴细胞凋亡与线粒体膜电位
Fetal Pediatr Pathol. 2011;30(1):45-52. doi: 10.3109/15513815.2010.505626.
4
Impaired avidity maturation after tetanus toxoid booster in children with Down syndrome.唐氏综合征患儿破伤风类毒素加强免疫后，亲和成熟受损。
Pediatr Infect Dis J. 2011 Apr;30(4):357-9. doi: 10.1097/INF.0b013e3181ff85a8.
5
Aging and immune function: molecular mechanisms to interventions.衰老与免疫功能：从分子机制到干预措施。
Antioxid Redox Signal. 2011 Apr 15;14(8):1551-85. doi: 10.1089/ars.2010.3228. Epub 2011 Jan 8.
6
Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system.唐氏综合征患儿呼吸道感染风险增加：免疫系统改变的后果。
Microbes Infect. 2010 Oct;12(11):799-808. doi: 10.1016/j.micinf.2010.05.007. Epub 2010 Jun 2.
7
Progeria syndromes and ageing: what is the connection?早衰综合征与衰老：有何关联？
Nat Rev Mol Cell Biol. 2010 Aug;11(8):567-78. doi: 10.1038/nrm2944.
8
Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome.唐氏综合征患儿外周血 T 细胞亚群、自然杀伤细胞及细胞因子水平分析。
Int J Immunogenet. 2010 Aug;37(4):233-7. doi: 10.1111/j.1744-313X.2010.00914.x. Epub 2010 Apr 30.
9
The effect of age on the response to the pneumococcal polysaccharide vaccine.年龄对肺炎球菌多糖疫苗反应的影响。
BMC Infect Dis. 2010 Mar 10;10:60. doi: 10.1186/1471-2334-10-60.
10
Both normal memory counts and decreased naive cells favor intrinsic defect over early senescence of Down syndrome T lymphocytes.正常的记忆细胞计数和幼稚细胞减少均表明唐氏综合征 T 淋巴细胞的内在缺陷而非早期衰老。
Pediatr Res. 2010 May;67(5):557-62. doi: 10.1203/PDR.0b013e3181d4eca3.
Zotero 插件