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T细胞生长因子及病毒纯化对病毒介导的淋巴细胞有丝分裂抑制作用的影响。

The effects of T-cell growth factor and virus purification on virus-mediated inhibition of lymphocyte mitogenesis.

作者信息

Wainberg M A, Margolese R G

出版信息

Clin Exp Immunol. 1982 Apr;48(1):163-70.

Abstract

Many different types of virus particles are able to non-specifically impede the ability of human peripheral blood lymphocytes to respond to mitogenic ro alloantigenic stimuli. This result is not obtained if ultra-purified virus is employed, although virus which has been banded only once through sucrose generally retains inhibitory potential. Ultra-pure virus is relatively unable to bind to cell surfaces, suggesting the importance of physical contact between viruses and cells in order for the observed inhibition to occur. Addition of exogenous T-cell growth factor (TCGF) to cultures containing virus, cells and stimulus causes a dose-dependent reversal of the usual inhibitory effect.

摘要

许多不同类型的病毒颗粒能够非特异性地阻碍人类外周血淋巴细胞对有丝分裂原或同种异体抗原刺激作出反应的能力。如果使用超纯病毒,则不会得到这样的结果,不过仅通过蔗糖一次密度梯度离心的病毒通常仍保留抑制潜能。超纯病毒相对无法与细胞表面结合,这表明病毒与细胞之间的物理接触对于出现所观察到的抑制作用很重要。向含有病毒、细胞和刺激物的培养物中添加外源性T细胞生长因子(TCGF)会导致通常的抑制作用出现剂量依赖性逆转。

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