风疹病毒在人单核血细胞中的复制
Replication of rubella virus in human mononuclear blood cells.
作者信息
van der Logt J T, van Loon A M, van der Veen J
出版信息
Infect Immun. 1980 Feb;27(2):309-14. doi: 10.1128/iai.27.2.309-314.1980.
Rubella virus was capable of replicating in both unstimulated and phytohemagglutinin-stimulated cultures of human mononuclear blood cells. Monocyte-derived macrophages were the main cell type responsible for viral replication. The susceptibility of macrophages increased during cultivation. Phytohemagglutinin-stimulated lymphocytes were able to support replication to a limited degree. No viral replication was detected in unstimulated lymphocytes. Both stimulation and viral replication in phytohemagglutinin-treated lymphocyte cultures were enhanced by the addition of murine macrophages. Human leukocyte interferon depressed the production of virus in these combined cultures. The finding that rubella virus is able to replicate in human lymphocytes as well as in macrophages may contribute to understanding the mechanisms of the suppressive effect of the virus on in vitro lymphocyte phytohemagglutinin responsiveness and in vivo immune functions.
风疹病毒能够在人单核血细胞的未刺激培养物和植物血凝素刺激培养物中复制。单核细胞衍生的巨噬细胞是负责病毒复制的主要细胞类型。巨噬细胞的易感性在培养过程中增加。植物血凝素刺激的淋巴细胞能够在有限程度上支持病毒复制。在未刺激的淋巴细胞中未检测到病毒复制。在植物血凝素处理的淋巴细胞培养物中，添加鼠巨噬细胞可增强刺激和病毒复制。人白细胞干扰素可抑制这些混合培养物中的病毒产生。风疹病毒能够在人淋巴细胞以及巨噬细胞中复制这一发现，可能有助于理解该病毒对体外淋巴细胞植物血凝素反应性和体内免疫功能的抑制作用机制。
Zotero 插件