Tamm-Horsfall尿糖蛋白对人外周血淋巴细胞的刺激作用。
Stimulation of human peripheral blood lymphocytes by Tamm-Horsfall urinary glycoprotein.
作者信息
Hunt J S, McGiven A R
出版信息
Immunology. 1978 Aug;35(2):391-5.
Abstract
Tamm-Horsfall urinary glycoprotein (THP), prepared by salt precipitation of pooled urine from normal individuals, stimulated purified human peripheral blood lymphocytes (PBL) to undergo blastoid transformation. the response was measured by tritiated thymidine uptake into DNA after 6 days in culture. Several batches of THP stimulated, in varying degrees, all samples of PBL tested and the response approached that seen with the mitogens phytohaemagglutinin (PHA), Concanavalin A (Con A) and pokeweed mitogen (PWM) after 4 days in culture. The response usually exceeded that seen after 6 days with tuberculin purified protein derivative (PPD) in Mantoux positive lymphocyte donors.
摘要
通过对正常个体混合尿液进行盐沉淀制备的Tamm-Horsfall尿糖蛋白（THP），可刺激纯化的人外周血淋巴细胞（PBL）发生母细胞样转化。培养6天后，通过将氚标记的胸腺嘧啶核苷摄取到DNA中来测量反应。几批THP不同程度地刺激了所有测试的PBL样本，培养4天后的反应接近用丝裂原植物血凝素（PHA）、刀豆球蛋白A（Con A）和商陆丝裂原（PWM）所观察到的反应。在结核菌素纯化蛋白衍生物（PPD）刺激的曼氏阳性淋巴细胞供体中，培养6天后的反应通常超过此反应。
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Ultracentrifugation studies of a urinary mucoprotein which reacts with various viruses.对一种可与多种病毒发生反应的尿粘蛋白进行的超速离心研究。
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